Michael J Metzger
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Explore the profile of Michael J Metzger including associated specialties, affiliations and a list of published articles.
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27
Citations
737
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Recent Articles
11.
Keegan R, Talbot L, Chang Y, Metzger M, Dubnau J
PLoS Genet
. 2021 Apr;
17(4):e1009535.
PMID: 33886543
It has become increasingly clear that retrotransposons (RTEs) are more widely expressed in somatic tissues than previously appreciated. RTE expression has been implicated in a myriad of biological processes ranging...
12.
Yonemitsu M, Giersch R, Polo-Prieto M, Hammel M, Simon A, Cremonte F, et al.
Elife
. 2019 Nov;
8.
PMID: 31686650
Transmissible cancers, in which cancer cells themselves act as an infectious agent, have been identified in Tasmanian devils, dogs, and four bivalves. We investigated a disseminated neoplasia affecting geographically distant...
13.
Fernandez Robledo J, Yadavalli R, Allam B, Pales Espinosa E, Gerdol M, Greco S, et al.
Dev Comp Immunol
. 2018 Dec;
92:260-282.
PMID: 30503358
Bivalves, from raw oysters to steamed clams, are popular choices among seafood lovers and once limited to the coastal areas. The rapid growth of the aquaculture industry and improvement in...
14.
Horizontal transfer of retrotransposons between bivalves and other aquatic species of multiple phyla
Metzger M, Paynter A, Siddall M, Goff S
Proc Natl Acad Sci U S A
. 2018 Apr;
115(18):E4227-E4235.
PMID: 29669918
The LTR retrotransposon is a selfish endogenous element in the soft-shell clam genome that was first detected because of its dramatic amplification in bivalve transmissible neoplasia afflicting the species. We...
15.
Paynter A, Metzger M, Sessa J, Siddall M
Dis Aquat Organ
. 2017 Apr;
124(2):165-168.
PMID: 28425429
Bivalve specimens from legacy frozen tissue collections, and others freshly obtained, were surveyed for the presence of the Steamer long terminal repeat (LTR)-retrotransposon associated with disseminated hemic neoplasia of the...
16.
17.
Metzger M, Villalba A, Carballal M, Iglesias D, Sherry J, Reinisch C, et al.
Nature
. 2016 Jun;
534(7609):705-9.
PMID: 27338791
Most cancers arise from oncogenic changes in the genomes of somatic cells, and while the cells may migrate by metastasis, they remain within that single individual. Natural transmission of cancer...
18.
Metzger M, Reinisch C, Sherry J, Goff S
Cell
. 2015 Apr;
161(2):255-63.
PMID: 25860608
Outbreaks of fatal leukemia-like cancers of marine bivalves throughout the world have led to massive population loss. The cause of the disease is unknown. We recently identified a retrotransposon, Steamer,...
19.
Arriagada G, Metzger M, Muttray A, Sherry J, Reinisch C, Street C, et al.
Proc Natl Acad Sci U S A
. 2014 Sep;
111(39):14175-80.
PMID: 25201971
Bivalve mollusks of the North Atlantic, most prominently the soft shell clam Mya arenaria, are afflicted with an epidemic transmissible disease of the circulatory system closely resembling leukemia. The disease...
20.
Metzger M, Certo M
Methods Mol Biol
. 2014 Feb;
1114:237-44.
PMID: 24557907
Single-strand nicking endonucleases ("nickases") have been shown to induce homology-mediated gene correction with reduced toxicity of DNA double-strand break-producing enzymes, and nickases have been engineered from both homing endonuclease and...