Michael J McKinley
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Explore the profile of Michael J McKinley including associated specialties, affiliations and a list of published articles.
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54
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913
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Recent Articles
1.
Peiris R, May C, Booth L, McAllen R, McKinley M, Hood S, et al.
Intensive Care Med Exp
. 2023 Aug;
11(1):53.
PMID: 37535121
Background: The autonomic nervous system can modulate the innate immune responses to bacterial infections via the splanchnic sympathetic nerves. Here, we aimed to determine the effects of bilateral splanchnic sympathetic...
2.
Occhinegro A, McAllen R, McKinley M, Martelli D
Neuroimmunomodulation
. 2023 Jun;
30(1):135-142.
PMID: 37302390
In this review, we will try to convince the readers that the immune system is controlled by an endogenous neural reflex, termed inflammatory reflex, that inhibits the acute immune response...
3.
McKinley M, Martelli D, Trevizan-Bau P, McAllen R
J Physiol
. 2022 Sep;
600(20):4521-4536.
PMID: 36056471
The efferent branches of the splanchnic sympathetic nerves that enhance interleukin-10 (IL-10) and suppress tumour necrosis factor-α (TNF) levels in the reflex response to systemic immune challenge were investigated in...
4.
McAllen R, McKinley M, Martelli D
Auton Neurosci
. 2021 Dec;
237:102926.
PMID: 34906897
This short review focusses on the inflammatory reflex, which acts in negative feedback manner to moderate the inflammatory consequences of systemic microbial challenge. The historical development of the inflammatory reflex...
5.
Occhinegro A, Wong C, Chua B, Jackson D, McKinley M, McAllen R, et al.
Brain Behav Immun
. 2021 Aug;
97:371-375.
PMID: 34333113
The splanchnic anti-inflammatory pathway, the efferent arm of the endogenous inflammatory reflex, has been shown to suppress the acute inflammatory response of rats to systemic lipopolysaccharide (LPS). Here we show...
6.
McKinley M, Pennington G, Ryan P
Handb Clin Neurol
. 2021 Jul;
179:435-454.
PMID: 34225980
Located in the midline lamina terminalis of the anterior wall of the third ventricle, the median preoptic nucleus is a thin elongated nucleus stretching around the rostral border of the...
7.
Lankadeva Y, May C, McKinley M, Neeland M, Ma S, Hocking D, et al.
Sci Rep
. 2020 Sep;
10(1):15009.
PMID: 32929135
A neural reflex mediated by the splanchnic sympathetic nerves regulates systemic inflammation in negative feedback fashion, but its consequences for host responses to live infection are unknown. To test this,...
8.
Saker P, Carey S, Grohmann M, Farrell M, Ryan P, Egan G, et al.
Proc Natl Acad Sci U S A
. 2020 Jun;
117(24):13750-13756.
PMID: 32482871
In response to dehydration, humans experience thirst. This subjective state is fundamental to survival as it motivates drinking, which subsequently corrects the fluid deficit. To elicit thirst, previous studies have...
9.
McKinley M, Denton D, Ryan P, Yao S, Stefanidis A, Oldfield B
J Neuroendocrinol
. 2019 Jan;
31(3):e12689.
PMID: 30672620
Much progress has been made during the past 30 years with respect to elucidating the neural and endocrine pathways by which bodily needs for water and energy are brought to...
10.
Martelli D, Farmer D, McKinley M, Yao S, McAllen R
Am J Physiol Regul Integr Comp Physiol
. 2018 Dec;
316(3):R235-R242.
PMID: 30576218
The splanchnic anti-inflammatory pathway has been proposed as the efferent arm of the inflammatory reflex. Although much evidence points to the spleen as the principal target organ where sympathetic nerves...