Derek A Denton
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Explore the profile of Derek A Denton including associated specialties, affiliations and a list of published articles.
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20
Citations
424
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Recent Articles
1.
Saker P, Carey S, Grohmann M, Farrell M, Ryan P, Egan G, et al.
Proc Natl Acad Sci U S A
. 2020 Jun;
117(24):13750-13756.
PMID: 32482871
In response to dehydration, humans experience thirst. This subjective state is fundamental to survival as it motivates drinking, which subsequently corrects the fluid deficit. To elicit thirst, previous studies have...
2.
McKinley M, Denton D, Ryan P, Yao S, Stefanidis A, Oldfield B
J Neuroendocrinol
. 2019 Jan;
31(3):e12689.
PMID: 30672620
Much progress has been made during the past 30 years with respect to elucidating the neural and endocrine pathways by which bodily needs for water and energy are brought to...
3.
Influence of anterior midcingulate cortex on drinking behavior during thirst and following satiation
Saker P, Farrell M, Egan G, McKinley M, Denton D
Proc Natl Acad Sci U S A
. 2018 Jan;
115(4):786-791.
PMID: 29311314
In humans, activity in the anterior midcingulate cortex (aMCC) is associated with both subjective thirst and swallowing. This region is therefore likely to play a prominent role in the regulation...
4.
Smith C, Walker L, Leeboonngam T, McKinley M, Denton D, Lawrence A
Proc Natl Acad Sci U S A
. 2016 Nov;
113(48):13893-13898.
PMID: 27849613
Due to the importance of dietary sodium and its paucity within many inland environments, terrestrial animals have evolved an instinctive sodium appetite that is commensurate with sodium deficiency. Despite a...
5.
Saker P, Farrell M, Egan G, McKinley M, Denton D
Proc Natl Acad Sci U S A
. 2016 Oct;
113(43):12274-12279.
PMID: 27791015
In humans, drinking replenishes fluid loss and satiates the sensation of thirst that accompanies dehydration. Typically, the volume of water drunk in response to thirst matches the deficit. Exactly how...
6.
Smith C, Walker L, Chua B, McKinley M, Gundlach A, Denton D, et al.
Exp Physiol
. 2015 Jul;
100(9):1064-72.
PMID: 26147879
What is the central question of this study? Sodium appetite is controlled by conserved neuronal transmitter-receptor systems. Here, we tested the contribution made by relaxin family peptide 3 receptor (RXFP3),...
7.
Saker P, Farrell M, Adib F, Egan G, McKinley M, Denton D
Proc Natl Acad Sci U S A
. 2014 Apr;
111(14):5379-84.
PMID: 24706817
The instinct of thirst was a cardinal element in the successful colonization by vertebrates of the dry land of the planet, which began in the Ordovician period about 400 million...
8.
Liedtke W, McKinley M, Walker L, Zhang H, Pfenning A, Drago J, et al.
Proc Natl Acad Sci U S A
. 2011 Jul;
108(30):12509-14.
PMID: 21746918
Sodium appetite is an instinct that involves avid specific intention. It is elicited by sodium deficiency, stress-evoked adrenocorticotropic hormone (ACTH), and reproduction. Genome-wide microarrays in sodium-deficient mice or after ACTH...
9.
Georgiadis J, Farrell M, Boessen R, Denton D, Gavrilescu M, Kortekaas R, et al.
Neuroimage
. 2009 Dec;
50(1):208-16.
PMID: 20006720
This study used arterial spin labeling (ASL) fMRI to measure brain perfusion in a group of healthy men under conditions that closely resembled customary sexual behavior. Serial perfusion measures for...
10.
Ramchandra R, Hood S, Denton D, Woods R, McKinley M, McAllen R, et al.
Proc Natl Acad Sci U S A
. 2009 Jan;
106(3):924-8.
PMID: 19136635
In heart failure (HF), sympathetic nerve activity is increased. Measurements in HF patients of cardiac norepinephrine spillover, reflecting cardiac sympathetic nerve activity (CSNA), indicate that it is increased earlier and...