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Michael J Matunis

Explore the profile of Michael J Matunis including associated specialties, affiliations and a list of published articles. Areas
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Articles 61
Citations 3306
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Recent Articles
1.
Zhao R, Wivagg A, Lackner R, Salsman J, Dellaire G, Matunis M, et al.
bioRxiv . 2025 Feb; PMID: 39896638
Many cancers use an alternative lengthening of telomeres (ALT) pathway for telomere maintenance. ALT telomeric DNA synthesis occurs in ALT telomere-associated PML bodies (APBs). However, the mechanisms by which APBs...
2.
Shkolnik D, Dey S, Hasan M, Matunis M, Brik A
Chem Sci . 2024 Nov; 16(1):191-198. PMID: 39600502
The Small Ubiquitin-like Modifier (SUMO) is a crucial post-translational modifier of proteins, playing a key role in various cellular functions. All SUMOs are synthesized as precursor proteins that must be...
3.
Wang W, Matunis M
Cells . 2024 Jan; 13(1). PMID: 38201212
Small ubiquitin-related modifiers (SUMOs) function as post-translational protein modifications and regulate nearly every aspect of cellular function. While a single ubiquitin protein is expressed across eukaryotic organisms, multiple SUMO paralogues...
4.
Wang W, Lu J, Yang W, Spear E, Michaelis S, Matunis M
J Biol Chem . 2023 Jan; 299(2):102851. PMID: 36587767
Misfolded proteins are recognized and degraded through protein quality control (PQC) pathways, which are essential for maintaining proteostasis and normal cellular functions. Defects in PQC can result in disease, including...
5.
Ellis N, Zhu J, Yagle M, Yang W, Huang J, Kwako A, et al.
Front Genet . 2021 Dec; 12:753535. PMID: 34868226
Sumoylation is an important enhancer of responses to DNA replication stress and the SUMO-targeted ubiquitin E3 ligase RNF4 regulates these responses by ubiquitylation of sumoylated DNA damage response factors. The...
6.
Bouchard D, Wang W, Yang W, He S, Garcia A, Matunis M
Mol Biol Cell . 2021 Jul; 32(19):1849-1866. PMID: 34232706
The small ubiquitin-related modifiers (SUMOs) regulate nearly every aspect of cellular function, from gene expression in the nucleus to ion transport at the plasma membrane. In humans, the SUMO pathway...
7.
Jacob J, Nair R, Poll B, Pineda C, Hobbs R, Matunis M, et al.
J Cell Sci . 2020 Oct; 133(20). PMID: 33008845
Keratin 17 (; K17), a non-lamin intermediate filament protein, was recently found to occur in the nucleus. We report here on K17-dependent differences in nuclear morphology, chromatin organization, and cell...
8.
Bouchard D, Matunis M
J Gastrointest Oncol . 2019 Oct; 10(5):821-830. PMID: 31602319
Sumoylation is an important post-translational modification that involves the conjugation of the Small Ubiquitin-related Modifier (SUMO) onto target proteins. This modification is reversed through the catalytic activity of SUMO isopeptidases,...
9.
Lee C, Li B, Yu H, Matunis M
Bio Protoc . 2018 Dec; 8(19). PMID: 30505883
The Small Ubiquitin-related Modifier (SUMO) is a protein that is post-translationally added to and reversibly removed from other proteins in eukaryotic cells. SUMO and enzymes of the SUMO pathway are...
10.
Odeh H, Coyaud E, Raught B, Matunis M
Mol Biol Cell . 2018 Jun; 29(15):1878-1890. PMID: 29874116
Sumoylation regulates a wide range of essential cellular functions, many of which are associated with activities in the nucleus. Although there is also emerging evidence for the involvement of the...