Michael J Harms
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Explore the profile of Michael J Harms including associated specialties, affiliations and a list of published articles.
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50
Citations
1279
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Recent Articles
1.
Chisholm L, Jeon C, Prell J, Harms M
bioRxiv
. 2024 Aug;
PMID: 39185185
S100A9 is a Damage Associated Molecular Pattern (DAMP) that activates the innate immune system via Toll-like receptor 4 (TLR4). Despite many years of study, the mechanism of activation remains unknown....
2.
Garcia A, Shavlik M, Harms M, Pluth M
Chemistry
. 2024 Aug;
30(57):e202401981.
PMID: 39136587
Cucurbit[n]urils (CB[n]s) are cyclic macrocycles with rich host-guest chemistry. In many cases, guest binding in CB[n]s results in host structural deformations. Unfortunately, measuring such deformations remains a major challenge, with...
3.
Orlandi K, Harms M
bioRxiv
. 2024 Jul;
PMID: 38979154
The protein heterodimer calprotectin and its component proteins, S100A8 and S100A9, play important antibacterial and proinflammatory roles in the mammalian innate immune response. Gaining mechanistic insights into the regulation and...
4.
Glenn S, Gentry-Lear Z, Shavlik M, Harms M, Asaki T, Baylink A
Elife
. 2024 May;
12.
PMID: 38820052
Bacteria of the family Enterobacteriaceae are associated with gastrointestinal (GI) bleeding and bacteremia and are a leading cause of death, from sepsis, for individuals with inflammatory bowel diseases. The bacterial...
5.
Chisholm L, Jaeger N, Murawsky H, Harms M
bioRxiv
. 2024 May;
PMID: 38798518
S100A9 is a Damage Associated Molecular Pattern (DAMP) that activates inflammatory pathways via Toll-like receptor 4 (TLR4). This activity plays important homeostatic roles in tissue repair, but can also contribute...
6.
Nixon C, Lim S, Sternke M, Barrick D, Harms M, Marqusee S
Protein Sci
. 2024 May;
33(6):e5011.
PMID: 38747388
A protein sequence encodes its energy landscape-all the accessible conformations, energetics, and dynamics. The evolutionary relationship between sequence and landscape can be probed phylogenetically by compiling a multiple sequence alignment...
7.
Tran T, Narayanan C, Loes A, Click T, Pham N, Letourneau M, et al.
J Biol Chem
. 2024 Apr;
300(5):107280.
PMID: 38588810
Evolutionarily conserved structural folds can give rise to diverse biological functions, yet predicting atomic-scale interactions that contribute to the emergence of novel activities within such folds remains challenging. Pancreatic-type ribonucleases...
8.
Franco K, Gentry-Lear Z, Shavlik M, Harms M, Baylink A
bioRxiv
. 2024 Jan;
PMID: 38293242
Chemotaxis controls motility and colonization in many enteric pathogens, yet most studies have examined bacterial responses to single effectors in isolation. Previously, we reported that Typhimurium uses the chemoreceptor Tsr...
9.
Chisholm L, Orlandi K, Phillips S, Shavlik M, Harms M
Annu Rev Biophys
. 2023 Dec;
53(1):127-146.
PMID: 38134334
A protein's sequence determines its conformational energy landscape. This, in turn, determines the protein's function. Understanding the evolution of new protein functions therefore requires understanding how mutations alter the protein...
10.
Glenn S, Gentry-Lear Z, Shavlik M, Harms M, Asaki T, Baylink A
bioRxiv
. 2023 Jul;
PMID: 37461633
Bacteria of the family Enterobacteriaceae are associated with gastrointestinal (GI) bleeding and bacteremia and are a leading cause of death, from sepsis, for individuals with inflammatory bowel diseases. The bacterial...