Michael J Hamill
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Explore the profile of Michael J Hamill including associated specialties, affiliations and a list of published articles.
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8
Citations
77
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Recent Articles
1.
Daou N, Viader A, Cokol M, Nitzel A, Chakravarthy M, Afeyan R, et al.
Sci Rep
. 2021 Jun;
11(1):11861.
PMID: 34088912
Nonalcoholic steatohepatitis (NASH) is a complex metabolic disease of heterogeneous and multifactorial pathogenesis that may benefit from coordinated multitargeted interventions. Endogenous metabolic modulators (EMMs) encompass a broad set of molecular...
2.
Hamill M, Afeyan R, Chakravarthy M, Tramontin T
iScience
. 2020 Oct;
23(10):101628.
PMID: 33103071
Multifactorial disease pathophysiology is complex and incompletely addressed by existing targeted pharmacotherapies. Amino acids (AAs) and related metabolites and precursors are a class of endogenous metabolic modulators (EMMs) that have...
3.
Hamill M, Jost M, Wong C, Bene N, Drennan C, Elliott S
Int J Mol Sci
. 2013 Feb;
13(12):16899-915.
PMID: 23443126
When exposed to known DNA-damaging alkylating agents, Escherichia coli cells increase production of four DNA repair enzymes: Ada, AlkA, AlkB, and AidB. The role of three enzymes (Ada, AlkA, and...
4.
Goldman P, Ryan K, Hamill M, Howard-Jones A, Walsh C, Elliott S, et al.
Chem Biol
. 2012 Jul;
19(7):855-65.
PMID: 22840773
The indolocarbazole biosynthetic enzymes StaC, InkE, RebC, and AtmC mediate the degree of oxidation of chromopyrrolic acid on route to the natural products staurosporine, K252a, rebeccamycin, and AT2433-A1, respectively. Here,...
5.
Hamill M, Jost M, Wong C, Elliott S, Drennan C
Biochemistry
. 2011 Oct;
50(46):10159-69.
PMID: 22004173
The process known as "adaptive response" allows Escherichia coli to respond to small doses of DNA-methylating agents by upregulating the expression of four proteins. While the role of three of...
6.
Hamill M, Chobot S, Hernandez H, Drennan C, Elliott S
Biochemistry
. 2008 Aug;
47(37):9738-46.
PMID: 18717594
Thioredoxin reductases (TrxRs) are flavin-containing dithioloxidoreductases that couple reduction equivalents from the soluble NAD(P)H pool to the soluble protein thioredoxin (Trx). Previous crystallographic studies of the Escherichia coli enzyme (...
7.
Hernandez H, Jaquez O, Hamill M, Elliott S, Drennan C
Biochemistry
. 2008 Aug;
47(37):9728-37.
PMID: 18717593
Thioredoxin reductases (TrxRs) regulate the intracellular redox environment by using NADPH to provide reducing equivalents for thioredoxins (Trxs). Here we present the cloning and biochemical characterization of a putative TrxR...
8.
Ryan K, Howard-Jones A, Hamill M, Elliott S, Walsh C, Drennan C
Proc Natl Acad Sci U S A
. 2007 Sep;
104(39):15311-6.
PMID: 17873060
The biosynthesis of rebeccamycin, an antitumor compound, involves the remarkable eight-electron oxidation of chlorinated chromopyrrolic acid. Although one rebeccamycin biosynthetic enzyme is capable of generating low levels of the eight-electron...