Michael J Federle
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Explore the profile of Michael J Federle including associated specialties, affiliations and a list of published articles.
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66
Citations
2523
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Recent Articles
1.
Feldstein S, Rahbari K, Leonardo T, Alvernaz S, Federle M
bioRxiv
. 2025 Feb;
PMID: 39975246
, or Group A Streptococus (GAS), a significant human pathogen, employs quorum sensing (QS) systems to coordinate its behavior and genetic regulation in order to enhance survival. Our previous research...
2.
Woo J, Zimnicka A, Federle M, Freitag N
Microbiol Spectr
. 2024 Oct;
12(11):e0048524.
PMID: 39387597
Carbon catabolite repression (CCR) is a widely conserved regulatory process that ensures enzymes and transporters of less-preferred carbohydrates are transcriptionally repressed in the presence of a preferred carbohydrate. This phenomenon...
3.
Wilkening R, Langouet-Astrie C, Severn M, Federle M, Horswill A
Cell Rep
. 2023 Oct;
42(11):113332.
PMID: 37889753
Streptococcus pyogenes is an obligate human pathobiont associated with many disease states. Here, we present a model of S. pyogenes infection using intact murine epithelium. We were able to perform...
4.
Hu D, Laczkovich I, Federle M, Morrison D
J Bacteriol
. 2023 Jun;
205(7):e0008723.
PMID: 37341600
Streptococcus pneumoniae is an agent of otitis media, septicemia, and meningitis and remains the leading cause of community-acquired pneumonia regardless of vaccine use. Of the various strategies that S. pneumoniae...
5.
Nepomuceno V, Tylor K, Carlson S, Federle M, Murphy B, Perez Morales T
Microbiol Spectr
. 2023 Jun;
11(4):e0527922.
PMID: 37284782
Quorum sensing (QS) is a means of bacterial communication accomplished by microbe-produced signals and sensory systems. QS systems regulate important population-wide behaviors in bacteria, including secondary metabolite production, swarming motility,...
6.
Rued B, Federle M
J Bacteriol
. 2023 May;
205(6):e0008923.
PMID: 37195233
The ability to take up and incorporate foreign DNA via natural transformation is a well-known characteristic of some species of Streptococcus, and is a mechanism that rapidly allows for the...
7.
Rued B, Federle M
bioRxiv
. 2023 Mar;
PMID: 36945404
Importance: Natural transformation is the process by which bacteria take up DNA and allows for acquisition of new genetic traits, including those involved in antibiotic resistance. This study demonstrates that...
8.
Resko Z, Anderson C, Federle M, Alonzo 3rd F
Infect Immun
. 2023 Jan;
91(2):e0050022.
PMID: 36715551
The peptidoglycan of Staphylococcus aureus is a critical cell envelope constituent and virulence factor that subverts host immune defenses and provides protection against environmental stressors. Peptidoglycan chains of the S....
9.
Rued B, Anderson C, Federle M
J Bacteriol
. 2022 Oct;
204(11):e0017522.
PMID: 36314832
Streptococcus pyogenes, otherwise known as Group A Streptococcus (GAS), is an important and highly adaptable human pathogen with the ability to cause both superficial and severe diseases. Understanding how S....
10.
Chang J, Wilkening R, Rahbari K, Federle M
J Bacteriol
. 2022 Aug;
204(9):e0017622.
PMID: 35938850
Cell-cell signaling mediated by Rgg-family transcription factors and their cognate pheromones is conserved in , including all streptococci. In Streptococcus pyogenes, or group A strep (GAS), one of these systems,...