Matthew B Neiditch
Overview
Explore the profile of Matthew B Neiditch including associated specialties, affiliations and a list of published articles.
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36
Citations
1306
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Recent Articles
1.
Warapande V, Meng F, Bozan A, Graff D, Fromer J, Mughal K, et al.
bioRxiv
. 2025 Feb;
PMID: 39974961
Drug discovery is inherently challenged by a multiple criteria decision making problem. The arduous path from hit discovery through lead optimization and preclinical candidate selection necessitates the evolution of a...
2.
Guarnaccia A, Ng W, Steenhaut A, Olenic S, Perez L, Neiditch M
J Clin Transl Sci
. 2023 Jul;
7(1):e134.
PMID: 37396816
[This corrects the article DOI: 10.1017/cts.2023.503.].
3.
Ahmed I, Hahn J, Henrickson A, Khaja F, Demeler B, Dubnau D, et al.
Nat Commun
. 2022 Dec;
13(1):7724.
PMID: 36513643
An essential step in bacterial transformation is the uptake of DNA into the periplasm, across the thick peptidoglycan cell wall of Gram-positive bacteria, or the outer membrane and thin peptidoglycan...
4.
Rudraraju R, Daher S, Gallardo-Macias R, Wang X, Neiditch M, Freundlich J
Front Cell Infect Microbiol
. 2022 Oct;
12:1008213.
PMID: 36189349
Recent studies have reported the β-ketoacyl-acyl carrier protein KasA as a druggable target for . This review summarizes the current status of major classes of KasA inhibitors with an emphasis...
5.
Hsueh B, Severin G, Elg C, Waldron E, Kant A, Wessel A, et al.
Nat Microbiol
. 2022 Jul;
7(8):1210-1220.
PMID: 35817890
Vibrio cholerae biotype El Tor is perpetuating the longest cholera pandemic in recorded history. The genomic islands VSP-1 and VSP-2 distinguish El Tor from previous pandemic V. cholerae strains. Using...
6.
Klancher C, Minasov G, Podicheti R, Rusch D, Dalia T, Satchell K, et al.
mBio
. 2021 Mar;
12(2).
PMID: 33727356
Sequence-specific DNA-binding domains (DBDs) are conserved in all domains of life. These proteins carry out a variety of cellular functions, and there are a number of distinct structural domains already...
7.
Puhl A, Lane T, Vignaux P, Zorn K, Capodagli G, Neiditch M, et al.
ACS Omega
. 2020 Nov;
5(46):29935-29942.
PMID: 33251429
Tuberculosis is caused by and is a deadly disease resulting in the deaths of approximately 1.5 million people with 10 million infections reported in 2018. Recently, a key condensation step...
8.
Capodagli G, Tylor K, Kaelber J, Petrou V, Federle M, Neiditch M
Proc Natl Acad Sci U S A
. 2020 Sep;
117(39):24494-24502.
PMID: 32907945
Regulator gene of glucosyltransferase (Rgg) family proteins, such as Rgg2 and Rgg3, have emerged as primary quorum-sensing regulated transcription factors in species, controlling virulence, antimicrobial resistance, and biofilm formation. Rgg2...
9.
Mhatre E, Snyder D, Sileo E, Turner C, Buskirk S, Fernandez N, et al.
Proc Natl Acad Sci U S A
. 2020 Aug;
117(35):21647-21657.
PMID: 32817433
Many bacteria cycle between sessile and motile forms in which they must sense and respond to internal and external signals to coordinate appropriate physiology. Maintaining fitness requires genetic networks that...
10.
Inoyama D, Awasthi D, Capodagli G, Tsotetsi K, Sukheja P, Zimmerman M, et al.
Cell Chem Biol
. 2020 Mar;
27(5):560-570.e10.
PMID: 32197094
Published Mycobacterium tuberculosis β-ketoacyl-ACP synthase KasA inhibitors lack sufficient potency and/or pharmacokinetic properties. A structure-based approach was used to optimize existing KasA inhibitor DG167. This afforded indazole JSF-3285 with a...