Michael J Chappell
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Explore the profile of Michael J Chappell including associated specialties, affiliations and a list of published articles.
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31
Citations
174
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Recent Articles
1.
Tsakonas P, Evans N, Hardwicke J, Chappell M
Annu Int Conf IEEE Eng Med Biol Soc
. 2025 Mar;
2024:1-5.
PMID: 40039739
This paper presents parameter estimation for the passive moment and musculoskeletal scaling coefficients of a mathematical model describing the equations of motion of human finger segments. A novel musculoskeletal model...
2.
Wanika L, Evans N, Johnson M, Tomkinson H, Chappell M
Clin Transl Sci
. 2024 Mar;
17(3):e13714.
PMID: 38477045
Tyrosine kinase inhibitors (TKIs) are routinely prescribed for the treatment of non-small cell lung cancer (NSCLC). As with all medications, patients can experience adverse events due to TKIs. Unfortunately, the...
3.
Tsakonas P, Neil E, Hardwicke J, Chappell M
Healthc Technol Lett
. 2024 Feb;
11(1):1-15.
PMID: 38370164
The goal of this paper is twofold: firstly, to provide a novel mathematical model that describes the kinematic chain of motion of the human fingers based on Lagrangian mechanics with...
4.
Tindall M, Chappell M, Yates J
Int J Antimicrob Agents
. 2022 Jul;
60(4):106641.
PMID: 35872295
Mathematical modelling has made significant contributions to the optimization of the use of antimicrobial treatments. This article discusses the key processes that such mathematical modelling should attempt to capture. In...
5.
Carter S, Chouhan B, Sharma P, Chappell M
CPT Pharmacometrics Syst Pharmacol
. 2020 Mar;
9(4):211-221.
PMID: 32142598
A structurally identifiable micro-rate constant mechanistic model was used to describe the interaction between pitavastatin and eltrombopag, with improved goodness-of-fit values through comeasurement of pitavastatin and eltrombopag. Transporter association and...
6.
Catherwood A, Lloyd A, Tod J, Chauhan S, Slade S, Walkowiak G, et al.
J Am Chem Soc
. 2020 Feb;
142(11):5034-5048.
PMID: 32048840
Penicillin binding proteins (PBPs) catalyzing transpeptidation reactions that stabilize the peptidoglycan component of the bacterial cell wall are the targets of β-lactams, the most clinically successful antibiotics to date. However,...
7.
Carter S, Ferecsko A, King L, Menochet K, Parton T, Chappell M
Xenobiotica
. 2019 Aug;
50(4):415-426.
PMID: 31389297
Determine the inhibition mechanism through which cyclosporine inhibits the uptake and metabolism of atorvastatin in fresh rat hepatocytes using mechanistic models applied to data generated using a high throughput oil...
8.
Kendrick F, Evans N, Berlanga O, Harding S, Chappell M
Front Immunol
. 2019 Apr;
10:674.
PMID: 31024535
Salvage of endogenous immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) is implicated in many clinical areas, including therapeutic monoclonal antibody kinetics, patient monitoring in IgG multiple myeloma, and...
9.
Cucurull-Sanchez L, Chappell M, Chelliah V, Cheung S, Derks G, Penney M, et al.
CPT Pharmacometrics Syst Pharmacol
. 2019 Jan;
8(5):259-272.
PMID: 30667172
The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts....
10.
Bunte K, Smith D, Chappell M, Hassan-Smith Z, Tomlinson J, Arlt W, et al.
J Theor Biol
. 2018 Jul;
455:222-231.
PMID: 30048717
To understand trends in individual responses to medication, one can take a purely data-driven machine learning approach, or alternatively apply pharmacokinetics combined with mixed-effects statistical modelling. To take advantage of...