Michael J Chappell
Overview
Explore the profile of Michael J Chappell including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
31
Citations
174
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Janzen D, Jirstrand M, Chappell M, Evans N
Math Biosci
. 2017 Nov;
295:1-10.
PMID: 29107004
The concept of structural identifiability for state-space models is expanded to cover mixed-effects state-space models. Two methods applicable for the analytical study of the structural identifiability of mixed-effects models are...
12.
Tragardh M, Chappell M, Palm J, Evans N, Janzen D, Gennemark P
Front Bioeng Biotechnol
. 2017 May;
5:24.
PMID: 28470000
Estimating the absorption profile of a drug is essential when developing extended-release medications. Such estimates can be obtained by measuring plasma concentrations over time and inferring the absorption from a...
13.
Wong H, Tiffin P, Chappell M, Nichols T, Welsh P, Doyle O, et al.
Front Physiol
. 2017 Apr;
8:199.
PMID: 28443027
Attention-Deficit Hyperactive Disorder (ADHD) is one of the most common mental health disorders amongst school-aged children with an estimated prevalence of 5% in the global population (American Psychiatric Association, 2013)....
14.
Kendrick F, Evans N, Arnulf B, Avet-Loiseau H, Decaux O, Dejoie T, et al.
Front Physiol
. 2017 Apr;
8:149.
PMID: 28367126
Immunoglobulin G (IgG) metabolism has received much attention in the literature for two reasons: (i) IgG homeostasis is regulated by the neonatal Fc receptor (FcRn), by a pH-dependent and saturable...
15.
Janzen D, Bergenholm L, Jirstrand M, Parkinson J, Yates J, Evans N, et al.
Front Physiol
. 2016 Dec;
7:590.
PMID: 27994553
Issues of parameter identifiability of routinely used pharmacodynamics models are considered in this paper. The structural identifiability of 16 commonly applied pharmacodynamic model structures was analyzed analytically, using the input-output...
16.
Chappell M, Dickson J, Radde N, Chase J
Math Biosci
. 2016 Dec;
284:1-2.
PMID: 27979679
No abstract available.
17.
Janzen D, Jirstrand M, Chappell M, Evans N
Comput Methods Programs Biomed
. 2016 May;
171:141-152.
PMID: 27181677
Background And Objective: Structural identifiability is a concept that considers whether the structure of a model together with a set of input-output relations uniquely determines the model parameters. In the...
18.
Tragardh M, Chappell M, Ahnmark A, Linden D, Evans N, Gennemark P
J Pharmacokinet Pharmacodyn
. 2016 Mar;
43(2):207-21.
PMID: 26932466
Input estimation is employed in cases where it is desirable to recover the form of an input function which cannot be directly observed and for which there is no model...
19.
Bergenholm L, Collins T, Evans N, Chappell M, Parkinson J
J Pharmacol Toxicol Methods
. 2016 Jan;
79:34-44.
PMID: 26780675
Introduction: Pharmacokinetic-pharmacodynamic (PKPD) modelling can improve safety assessment, but few PKPD models describing drug-induced QRS and PR prolongations have been published. This investigation aims to develop and evaluate PKPD models...
20.
Andersson R, Jirstrand M, Peletier L, Chappell M, Evans N, Gabrielsson J
Eur J Pharm Sci
. 2015 Nov;
81:189-200.
PMID: 26529383
This study presents a dose-response-time (DRT) analysis based on a large preclinical biomarker dataset on the interaction between nicotinic acid (NiAc) and free fatty acids (FFA). Data were collected from...