Michael J Bradley
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Explore the profile of Michael J Bradley including associated specialties, affiliations and a list of published articles.
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25
Citations
579
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Recent Articles
1.
Moshirfar M, Waite A, Ellis J, Huynh R, Placide J, Barke M, et al.
Clin Ophthalmol
. 2021 Dec;
15:4667-4680.
PMID: 34934306
Purpose: To assess visual outcomes over time of femtosecond laser-assisted cataract surgery compared to standard phacoemulsification cataract surgery. Design: A retrospective, single-center comparative study. Methods: Patient data including demographics, ocular...
2.
Marineau J, Hamman K, Hu S, Alnemy S, Mihalich J, Kabro A, et al.
J Med Chem
. 2021 Nov;
65(2):1458-1480.
PMID: 34726887
CDK7 has emerged as an exciting target in oncology due to its roles in two important processes that are misregulated in cancer cells: cell cycle and transcription. This report describes...
3.
Rimel J, Poss Z, Erickson B, Maas Z, Ebmeier C, Johnson J, et al.
Genes Dev
. 2020 Oct;
34(21-22):1452-1473.
PMID: 33060135
CDK7 associates with the 10-subunit TFIIH complex and regulates transcription by phosphorylating the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Few additional CDK7 substrates are known. Here, using the...
4.
Hu S, Marineau J, Rajagopal N, Hamman K, Choi Y, Schmidt D, et al.
Cancer Res
. 2019 May;
79(13):3479-3491.
PMID: 31064851
Recent studies suggest that targeting transcriptional machinery can lead to potent and selective anticancer effects in cancers dependent on high and constant expression of certain transcription factors for growth and...
5.
Hocky G, Baker J, Bradley M, Sinitskiy A, De La Cruz E, Voth G
J Phys Chem B
. 2016 May;
120(20):4558-67.
PMID: 27146246
Ions regulate the assembly and mechanical properties of actin filaments. Recent work using structural bioinformatics and site-specific mutagenesis favors the existence of two discrete and specific divalent cation binding sites...
6.
Kang H, Bradley M, Cao W, Zhou K, Grintsevich E, Michelot A, et al.
Proc Natl Acad Sci U S A
. 2014 Dec;
111(50):17821-6.
PMID: 25468977
Actin polymerization powers the directed motility of eukaryotic cells. Sustained motility requires rapid filament turnover and subunit recycling. The essential regulatory protein cofilin accelerates network remodeling by severing actin filaments...
7.
Kang H, Bradley M, Elam W, De La Cruz E
Biophys J
. 2013 Dec;
105(12):2621-8.
PMID: 24359734
Actin assembly, filament mechanical properties, and interactions with regulatory proteins depend on the types and concentrations of salts in solution. Salts modulate actin through both nonspecific electrostatic effects and specific...
8.
Xia S, Wood M, Bradley M, De La Cruz E, Konigsberg W
Nucleic Acids Res
. 2013 Aug;
41(19):9077-89.
PMID: 23921641
Internal cavities are a common feature of many proteins, often having profound effects on the dynamics of their interactions with substrate and binding partners. RB69 DNA polymerase (pol) has a...
9.
Kang H, Bradley M, McCullough B, Pierre A, Grintsevich E, Reisler E, et al.
Proc Natl Acad Sci U S A
. 2012 Oct;
109(42):16923-7.
PMID: 23027950
The assembly of actin monomers into filaments and networks plays vital roles throughout eukaryotic biology, including intracellular transport, cell motility, cell division, determining cellular shape, and providing cells with mechanical...
10.
Bradley M, De La Cruz E
Methods Enzymol
. 2012 Jun;
511:29-63.
PMID: 22713314
DEAD-box proteins (DBPs) couple ATP utilization to conformational rearrangement of RNA. In this chapter, we outline a combination of equilibrium and kinetic methods that have been developed and applied to...