Michael Hendzel
Overview
Explore the profile of Michael Hendzel including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
354
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Recent Articles
1.
Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes
Barbour H, Daou S, Hendzel M, Affar E
Nat Commun
. 2020 Nov;
11(1):5947.
PMID: 33230107
Histone posttranslational modifications are key regulators of chromatin-associated processes including gene expression, DNA replication and DNA repair. Monoubiquitinated histone H2A, H2Aub (K118 in Drosophila or K119 in vertebrates) is catalyzed...
2.
Cremer T, Cremer M, Hubner B, Silahtaroglu A, Hendzel M, Lanctot C, et al.
Bioessays
. 2020 Jan;
42(2):e1900132.
PMID: 31994771
This article focuses on the role of the interchromatin compartment (IC) in shaping nuclear landscapes. The IC is connected with nuclear pore complexes (NPCs) and harbors splicing speckles and nuclear...
3.
Good K, Martinez de Paz A, Tyagi M, Cheema M, Thambirajah A, Gretzinger T, et al.
Epigenetics
. 2017 Nov;
12(11):934-944.
PMID: 29099289
MeCP2 binds to methylated DNA in a chromatin context and has an important role in cancer and brain development and function. Histone deacetylase (HDAC) inhibitors are currently being used to...
4.
Hutchinson J, Cheema M, Wang J, Missiaen K, Finn R, Gonzalez Romero R, et al.
Biosci Rep
. 2015 Jul;
35(3).
PMID: 26182371
Although the details of the structural involvement of histone H1 in the organization of the nucleosome are quite well understood, the sequential events involved in the recognition of its binding...
5.
Stuss D, Cheema M, Ng M, Martinez de Paz A, Williamson B, Missiaen K, et al.
Nucleic Acids Res
. 2013 Apr;
41(9):4888-900.
PMID: 23558747
MeCP2 is a methyl-CpG-binding protein that is a main component of brain chromatin in vertebrates. In vitro studies have determined that in addition to its specific methyl-CpG-binding domain (MBD) MeCP2...
6.
Thambirajah A, Ng M, Frehlick L, Li A, Serpa J, Petrotchenko E, et al.
Nucleic Acids Res
. 2011 Dec;
40(7):2884-97.
PMID: 22144686
Methyl-CpG-binding protein 2 (MeCP2) is a chromatin-binding protein that mediates transcriptional regulation, and is highly abundant in brain. The nature of its binding to reconstituted templates has been well characterized...
7.
Furdas S, Shekfeh S, Bissinger E, Wagner J, Schlimme S, Valkov V, et al.
Bioorg Med Chem
. 2011 Mar;
19(12):3678-89.
PMID: 21353783
We present a combination of database screening, synthesis and in vitro testing to identify novel histone acetyltransferase (HAT) inhibitors. The National Cancer Institute compound collection (NCI) and several commercial databases...
8.
Hsu C, Hendzel M, Uluda H
J Gene Med
. 2011 Jan;
13(1):46-59.
PMID: 21259408
Background: Lipid substitutions of cationic polymers are actively explored to enhance the efficiency of nonviral gene carriers. We recently took this approach to develop a novel gene carrier by grafting...
9.
Rezania V, Tuszynski J, Hendzel M
Phys Biol
. 2008 Jan;
4(4):256-67.
PMID: 18185004
Surviving in a diverse environment requires corresponding organism responses. At the cellular level, such adjustment relies on the transcription factors (TFs) which must rapidly find their target sequences amidst a...
10.
Rodrigue A, Lafrance M, Gauthier M, McDonald D, Hendzel M, West S, et al.
EMBO J
. 2006 Jan;
25(1):222-31.
PMID: 16395335
DNA repair by homologous recombination is essential for preserving genomic integrity. The RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3) play important roles in this process. In this study, we...