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Michael Hackenberg

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Articles 84
Citations 2355
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Recent Articles
1.
Cerqueira de Araujo A, Noel B, Bretaudeau A, Labadie K, Boudet M, Tadrent N, et al.
BMC Biol . 2025 Jan; 23(1):17. PMID: 39838418
Background: Ticks, hematophagous Acari, pose a significant threat by transmitting various pathogens to their vertebrate hosts during feeding. Despite advances in tick genomics, high-quality genomes were lacking until recently, particularly...
2.
Clarke A, Hoye E, Hembrom A, Paynter V, Vinther J, Wyrozemski L, et al.
Nucleic Acids Res . 2024 Dec; 53(D1):D116-D128. PMID: 39673268
We present a major update of MirGeneDB (3.0), the manually curated animal microRNA gene database. Beyond moving to a new server and the creation of a computational mirror, we have...
3.
Scheepbouwer C, Aparicio-Puerta E, Gomez-Martin C, van Eijndhoven M, Drees E, Bosch L, et al.
bioRxiv . 2024 May; PMID: 38765958
Small extracellular vesicles (sEVs) are heterogenous lipid membrane particles typically less than 200 nm in size and secreted by most cell types either constitutively or upon activation signals. sEVs isolated...
4.
Giannoukakos S, DAmbrosi S, Koppers-Lalic D, Gomez-Martin C, Fernandez A, Hackenberg M
Heliyon . 2024 Mar; 10(6):e27360. PMID: 38515664
Liquid biopsy-derived RNA sequencing (lbRNA-seq) exhibits significant promise for clinic-oriented cancer diagnostics due to its non-invasiveness and ease of repeatability. Despite substantial advancements, obstacles like technical artefacts and process standardisation...
5.
van Eijndhoven M, Scheepbouwer C, Aparicio-Puerta E, Hackenberg M, Pegtel D
STAR Protoc . 2023 Oct; 4(4):102645. PMID: 37858475
Besides canonical microRNAs (miRNAs), sequence-based variations called isomiRs have biological relevance and diagnostic potential; however, accurate calling of these post-transcriptional modifications is challenging, especially for low input samples. Here, we...
6.
Zubkovic A, Gomes C, Parchure A, Cesarec M, Ferencic A, Rokic F, et al.
J Virol . 2023 Sep; 97(10):e0073023. PMID: 37712701
Herpes simplex virus 1 is an important human pathogen that has been intensively studied for many decades. Nevertheless, the molecular mechanisms regulating its establishment, maintenance, and reactivation from latency are...
7.
Garcia-Ortega M, Aparicio E, Grinan-Lison C, Jimenez G, Lopez-Ruiz E, Palacios J, et al.
Cancers (Basel) . 2023 Jul; 15(14). PMID: 37509327
Malignant melanoma (MM) can spread to other organs and is resistant in part due to the presence of cancer stem cell subpopulations (CSCs). While a controversial high dose of interferon-alpha...
8.
Gomez-Martin C, Aparicio-Puerta E, van Eijndhoven M, Medina J, Hackenberg M, Pegtel D
Cell Rep Methods . 2023 Jun; 3(5):100480. PMID: 37323569
IsomiRs, sequence variants of mature microRNAs, are usually detected and quantified using high-throughput sequencing. Many examples of their biological relevance have been reported, but sequencing artifacts identified as artificial variants...
9.
Scheepbouwer C, Hackenberg M, van Eijndhoven M, Gerber A, Pegtel M, Gomez-Martin C
Nucleic Acids Res . 2023 May; 51(W1):W372-W378. PMID: 37216599
RNA-sequencing has become one of the most used high-throughput approaches to gain knowledge about the expression of all different RNA subpopulations. However, technical artifacts, either introduced during library preparation and/or...
10.
Gomez-Martin C, Zhou H, Medina J, Aparicio-Puerta E, Shi B, Hackenberg M
Biomolecules . 2023 Mar; 13(3). PMID: 36979375
Wheat is one of the most important food sources on Earth. MicroRNAs (miRNAs) play important roles in wheat productivity. To identify wheat miRNAs as well as their expression profiles under...