Michail Kotsyfakis
Overview
Explore the profile of Michail Kotsyfakis including associated specialties, affiliations and a list of published articles.
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57
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1196
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Recent Articles
1.
Li J, Xiong W, Yang J, Gao Y, Chai J, Tian M, et al.
Eur J Pharmacol
. 2025 Feb;
991:177330.
PMID: 39892446
Psoriasis, a chronic inflammatory skin disorder, is characterized by a complex interplay among immune cells. Although the specific mechanisms of platelet involvement in psoriasis are not fully elucidated, platelet activation...
2.
Langhansova H, Berankova Z, Khanna R, Kotal J, Kotsyfakis M, Palus M, et al.
Parasitol Res
. 2025 Jan;
124(1):8.
PMID: 39821815
Tick-borne encephalitis virus (TBEV) is flavivirus transmitted to the host via tick saliva which contains various molecules with biological impacts. One of such molecules is Iristatin, a cysteine protease inhibitor...
3.
Chai J, Wu J, Yang J, Ye T, Gao Y, Zeng B, et al.
Int Immunopharmacol
. 2024 Oct;
143(Pt 1):113332.
PMID: 39395379
The clinical syndrome of sepsis arises from severe infection, triggering an abnormal immune response that can lead to multiple organ dysfunction and ultimately the death of the host. Current therapies...
4.
Xiong W, Chai J, Wu J, Li J, Lu W, Tian M, et al.
Research (Wash D C)
. 2024 Jun;
7:0381.
PMID: 38840901
Platelet activation contributes to sepsis development, leading to microthrombosis and increased inflammation, which results in disseminated intravascular coagulation and multiple organ dysfunction. Although Cathelicidin can alleviate sepsis, its role in...
5.
Wu H, Jmel M, Chai J, Tian M, Xu X, Hui Y, et al.
Front Immunol
. 2024 Mar;
15:1344878.
PMID: 38444844
Protease inhibitors regulate various biological processes and prevent host tissue/organ damage. Specific inhibition/regulation of proteases is clinically valuable for treating several diseases. Psoriasis affects the skin in the limbs and...
6.
Martins L, Busa M, Chlastakova A, Kotal J, Berankova Z, Stergiou N, et al.
Cell Mol Life Sci
. 2023 Oct;
80(11):339.
PMID: 37898573
Tick saliva injected into the vertebrate host contains bioactive anti-proteolytic proteins from the cystatin family; however, the molecular basis of their unusual biochemical and physiological properties, distinct from those of...
7.
Chai J, Wu J, Li J, Liao H, Lu W, Guo R, et al.
J Med Chem
. 2023 Aug;
66(17):11869-11880.
PMID: 37610210
Acute pancreatitis (AP) is a serious inflammatory disorder and still lacks effective therapy globally. In this study, a novel Ranacyclin peptide, Ranacin, was identified from the skin of frog. Ranacin...
8.
Abbas M, Jmel M, Mekki I, Dijkgraaf I, Kotsyfakis M
Int J Mol Sci
. 2023 Mar;
24(5).
PMID: 36902400
Ticks can seriously affect human and animal health around the globe, causing significant economic losses each year. Chemical acaricides are widely used to control ticks, which negatively impact the environment...
9.
Kotsyfakis M
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36769203
Arthropod disease vectors not only transmit malaria but many other serious diseases, many of which are, to a greater or lesser degree, neglected [...].
10.
Chlastakova A, Kascakova B, Kotal J, Langhansova H, Kotsyfakis M, Kuta Smatanova I, et al.
Front Immunol
. 2023 Feb;
14:1116324.
PMID: 36756125
Serpins are widely distributed and functionally diverse inhibitors of serine proteases. Ticks secrete serpins with anti-coagulation, anti-inflammatory, and immunomodulatory activities their saliva into the feeding cavity to modulate host's hemostatic...