Michael H B Stowell
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Explore the profile of Michael H B Stowell including associated specialties, affiliations and a list of published articles.
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38
Citations
733
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Recent Articles
1.
Powell W, Jing R, Herlory M, Holland P, Poliyenko D, Ebmeier C, et al.
J Am Chem Soc
. 2025 Feb;
147(8):6995-7007.
PMID: 39959999
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of tau protein aggregates. In this study, we investigated the effects of -glycosylation on tau, focusing on its impact...
2.
Sanner K, Kawell S, Evans J, Elekovic V, Walz M, Joksimovic S, et al.
bioRxiv
. 2025 Jan;
PMID: 39868306
The Ca 3.2 isoform of T-type voltage-gated calcium channels plays a crucial role in regulating the excitability of nociceptive neurons; the endogenous molecules that modulate its activity, however, remain poorly...
3.
Karolczak J, Przybylowska A, Szewczyk K, Taisner W, Heumann J, Stowell M, et al.
Bioinformatics
. 2024 Dec;
41(1).
PMID: 39700427
Motivation: Accurately identifying ligands plays a crucial role in the process of structure-guided drug design. Based on density maps from X-ray diffraction or cryogenic-sample electron microscopy (cryoEM), scientists verify whether...
4.
Powell W, Nahum M, Pankratz K, Herlory M, Greenwood J, Poliyenko D, et al.
ACS Cent Sci
. 2024 Dec;
10(11):2145-2161.
PMID: 39634209
The self-assembly of Tau into filaments, which mirror the structures observed in Alzheimer's disease (AD) brains, raises questions about the role of AD-specific post-translational modifications (PTMs) in the formation of...
5.
Karolczak J, Przybylowska A, Szewczyk K, Taisner W, Heumann J, Stowell M, et al.
bioRxiv
. 2024 Sep;
PMID: 39257821
Motivation: Accurately identifying ligands plays a crucial role in the process of structure-guided drug design. Based on density maps from X-ray diffraction or cryogenic-sample electron microscopy (cryoEM), scientists verify whether...
6.
Wang C, Jiang W, Leitz J, Yang K, Esquivies L, Wang X, et al.
Nature
. 2024 Jun;
631(8022):899-904.
PMID: 38838737
Synaptic vesicles are organelles with a precisely defined protein and lipid composition, yet the molecular mechanisms for the biogenesis of synaptic vesicles are mainly unknown. Here we discovered a well-defined...
7.
Hazlett Z, Xu B, Knight J, Klymkowsky M, Stowell M
Cell
. 2024 May;
187(11):2682-2686.
PMID: 38788690
Undergraduate students generally need laboratory skills and experience to be accepted into a position within an academic lab or a company. However, those settings are traditionally where students would develop...
8.
Powell W, Nahum M, Pankratz K, Herlory M, Greenwood J, Poliyenko D, et al.
bioRxiv
. 2024 Apr;
PMID: 38559065
The self-assembly of Tau(297-391) into filaments, which mirror the structures observed in Alzheimer's disease (AD) brains, raises questions about the role of AD-specific post-translational modifications (PTMs) in the formation of...
9.
Bhattacharjee B, Rahman M, Hibbs R, Stowell M
Front Mol Biosci
. 2023 Mar;
10:1129225.
PMID: 36959978
As the resolution revolution in CryoEM expands to encompass all manner of macromolecular complexes, an important new frontier is the implementation of cryogenic time resolved EM (cryoTREM). Biological macromolecular complexes...
10.
Wan C, Stowell M, Shen J
Commun Biol
. 2022 Nov;
5(1):1223.
PMID: 36369335
A fundamentally novel function proposed for extracellular vesicles (EVs) is to transfer bioactive molecules in intercellular signaling. In this minireview, we discuss recent progress on EV-mediated cargo transfer in the...