Michael Gotthardt
Overview
Explore the profile of Michael Gotthardt including associated specialties, affiliations and a list of published articles.
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83
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3496
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Recent Articles
1.
Huttemeister J, Rudolph F, Radke M, Fink C, Friedrich D, Preibisch S, et al.
Elife
. 2024 Dec;
13.
PMID: 39688479
The giant striated muscle protein titin integrates into the developing sarcomere to form a stable myofilament system that is extended as myocytes fuse. The logistics underlying myofilament assembly and disassembly...
2.
Crocini C, Gotthardt M
Biophys Rev
. 2024 May;
16(2):257.
PMID: 38737206
[This corrects the article DOI: 10.1007/s12551-021-00840-7.].
3.
Strom J, Bull M, Gohlke J, Saripalli C, Methawasin M, Gotthardt M, et al.
J Mol Cell Cardiol
. 2024 Apr;
191:40-49.
PMID: 38604403
The heart has the ability to detect and respond to changes in mechanical load through a process called mechanotransduction. In this study, we focused on investigating the role of the...
4.
Vad O, Angeli E, Liss M, Ahlberg G, Andreasen L, Christophersen I, et al.
JACC Basic Transl Sci
. 2024 Mar;
9(2):163-180.
PMID: 38510713
We showed an association between atrial fibrillation and rare loss-of-function (LOF) variants in the cardiac splicing regulator RBM20 in 2 independent cohorts. In a rat model with loss of ,...
5.
Gotthardt M, Lehnart S
Cardiovasc Res
. 2024 Feb;
120(3):220-222.
PMID: 38333928
No abstract available.
6.
Kornienko J, Rodriguez-Martinez M, Fenzl K, Hinze F, Schraivogel D, Grosch M, et al.
Nat Commun
. 2023 Jul;
14(1):4312.
PMID: 37463913
Severe forms of dilated cardiomyopathy (DCM) are associated with point mutations in the alternative splicing regulator RBM20 that are frequently located in the arginine/serine-rich domain (RS-domain). Such mutations can cause...
7.
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy
Grosch M, Schraft L, Chan A, Kuchenhoff L, Rapti K, Ferreira A, et al.
Nat Commun
. 2023 Jun;
14(1):3714.
PMID: 37349314
Dilated cardiomyopathy is the second most common cause for heart failure with no cure except a high-risk heart transplantation. Approximately 30% of patients harbor heritable mutations which are amenable to...
8.
Freiberg F, Thakkar M, Hamann W, Lopez Carballo J, Juttner R, Voss F, et al.
Exp Mol Med
. 2023 Mar;
55(3):643-652.
PMID: 36941462
The coxsackievirus and adenovirus receptor (CAR) mediates homo- and heterotopic interactions between neighboring cardiomyocytes at the intercalated disc. CAR is upregulated in the hypoxic areas surrounding myocardial infarction (MI). To...
9.
Sandmann C, Schulz J, Ruiz-Orera J, Kirchner M, Ziehm M, Adami E, et al.
Mol Cell
. 2023 Feb;
83(6):994-1011.e18.
PMID: 36806354
All species continuously evolve short open reading frames (sORFs) that can be templated for protein synthesis and may provide raw materials for evolutionary adaptation. We analyzed the evolutionary origins of...
10.
Matthaeus C, Juttner R, Gotthardt M, Rathjen F
Life (Basel)
. 2023 Jan;
13(1).
PMID: 36675963
The IgCAM coxsackie-adenovirus receptor (CAR) is essential for embryonic heart development and electrical conduction in the mature heart. However, it is not well-understood how CAR exerts these effects at the...