Stephan E Lehnart
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Explore the profile of Stephan E Lehnart including associated specialties, affiliations and a list of published articles.
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106
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4546
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Recent Articles
1.
Lahiri S, Lehnart S, Reilly S, Wehrens X
J Mol Cell Cardiol
. 2025 Jan;
199:78-79.
PMID: 39809341
No abstract available.
2.
Huttemeister J, Rudolph F, Radke M, Fink C, Friedrich D, Preibisch S, et al.
Elife
. 2024 Dec;
13.
PMID: 39688479
The giant striated muscle protein titin integrates into the developing sarcomere to form a stable myofilament system that is extended as myocytes fuse. The logistics underlying myofilament assembly and disassembly...
3.
Foo B, Amedei H, Kaur S, Jaawan S, Boshnakovska A, Gall T, et al.
PLoS One
. 2024 Oct;
19(10):e0311203.
PMID: 39446877
Phospholamban (PLN) is a sarco-endoplasmic reticulum (SER) membrane protein that regulates cardiac contraction/relaxation by reversibly inhibiting the SERCA2a Ca2+-reuptake pump. The R14Δ-PLN mutation causes severe cardiomyopathy that is resistant to...
4.
Paulke N, Fleischhacker C, Wegener J, Riedemann G, Cretu C, Mushtaq M, et al.
Circ Res
. 2024 Jul;
135(5):554-574.
PMID: 39011635
Background: Cardiac hypertrophy compensates for increased biomechanical stress of the heart induced by prevalent cardiovascular pathologies but can result in heart failure if left untreated. Here, we hypothesized that the...
5.
Lahiri S, Lu J, Aguilar-Sanchez Y, Li H, Moreira L, Hulsurkar M, et al.
J Mol Cell Cardiol
. 2024 Jul;
194:85-95.
PMID: 38960317
Coronary heart disease (CHD) is a prevalent cardiac disease that causes over 370,000 deaths annually in the USA. In CHD, occlusion of a coronary artery causes ischemia of the cardiac...
6.
Weninger G, Miotto M, Tchagou C, Reiken S, Dridi H, Brandenburg S, et al.
Proc Natl Acad Sci U S A
. 2024 Jun;
121(27):e2400497121.
PMID: 38917010
S100A1, a small homodimeric EF-hand Ca-binding protein (~21 kDa), plays an important regulatory role in Ca signaling pathways involved in various biological functions including Ca cycling and contractile performance in...
7.
Fakuade F, Hubricht D, Moller V, Sobitov I, Liutkute A, Doring Y, et al.
Circulation
. 2024 Jun;
150(7):544-559.
PMID: 38910563
Background: Alterations in the buffering of intracellular Ca, for which myofilament proteins play a key role, have been shown to promote cardiac arrhythmia. It is interesting that although studies report...
8.
Schwenzer N, Teiwes N, Kohl T, Pohl C, Giller M, Lehnart S, et al.
Commun Biol
. 2024 May;
7(1):620.
PMID: 38783117
A key player of excitable cells in the heart and brain is the L-type calcium channel Ca1.3. In the heart, it is required for voltage-dependent Ca-signaling, i.e., for controlling and...
9.
Dewenter M, Seitz T, Steinbrecher J, Westenbrink B, Ling H, Lehnart S, et al.
ESC Heart Fail
. 2024 Apr;
11(4):2191-2199.
PMID: 38616546
Aims: Hyperactivity of Ca/calmodulin-dependent protein kinase II (CaMKII) has emerged as a central cause of pathologic remodelling in heart failure. It has been suggested that CaMKII-induced hyperphosphorylation of the ryanodine...
10.
Pochechueva T, Schwenzer N, Kohl T, Brandenburg S, Kaltenecker G, Wollnik B, et al.
Int J Mol Sci
. 2024 Mar;
25(6).
PMID: 38542157
We present novel workflows for Q-FISH nanoscopy with the potential for prognostic applications and resolving novel chromatin compaction changes. DNA-fluorescence in situ hybridization (DNA-FISH) is a routine application to visualize...