Michael G Leeming
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Explore the profile of Michael G Leeming including associated specialties, affiliations and a list of published articles.
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31
Citations
121
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Recent Articles
11.
Russell I, Zhang X, Bumbak F, McNeill S, Josephs T, Leeming M, et al.
Biochemistry
. 2024 Feb;
63(5):625-631.
PMID: 38376112
The class A orphan G protein-coupled receptor (GPCR), GPR3, has been implicated in a variety of conditions, including Alzheimer's and premature ovarian failure. GPR3 constitutively couples with Gαs, resulting in...
12.
Shanley H, Taki A, Nguyen N, Wang T, Byrne J, Ang C, et al.
Int J Parasitol Drugs Drug Resist
. 2024 Jan;
24:100522.
PMID: 38295619
Within the context of our anthelmintic discovery program, we recently identified and evaluated a quinoline derivative, called ABX464 or obefazimod, as a nematocidal candidate; synthesised a series of analogues which...
13.
Structure activity relationship and target prediction for ABX464 analogues in Caenorhabditis elegans
Shanley H, Taki A, Nguyen N, Wang T, Byrne J, Ang C, et al.
Bioorg Med Chem
. 2023 Dec;
98:117540.
PMID: 38134663
Global challenges with treatment failures and/or widespread resistance in parasitic worms against commercially available anthelmintics lend impetus to the development of new anthelmintics with novel mechanism(s) of action. The free-living...
14.
Taki A, Ruethers T, Nugraha R, Karnaneedi S, Williamson N, Nie S, et al.
Allergy
. 2023 Aug;
78(12):3221-3234.
PMID: 37650248
Background: Major fish allergens, including parvalbumin (PV), are heat stable and can withstand extensive cooking processes. Thus, the management of fish allergy generally relies on complete avoidance. Fish-allergic patients may...
15.
Ameen S, Griem-Krey N, Dufour A, Hossain M, Hoque A, Sturgeon S, et al.
Mol Cell Proteomics
. 2023 Apr;
22(5):100543.
PMID: 37030595
Excitotoxicity, a neuronal death process in neurological disorders such as stroke, is initiated by the overstimulation of ionotropic glutamate receptors. Although dysregulation of proteolytic signaling networks is critical for excitotoxicity,...
16.
Leeming M, Ang C, Nie S, Varshney S, Williamson N
Bioinform Adv
. 2023 Jan;
3(1):vbac096.
PMID: 36698761
Motivation: A large number of experimental and bioinformatic parameters must be set to identify and quantify peptides in mass spectrometry experiments and each of these will impact the results. An...
17.
Taki A, Wang T, Nguyen N, Ang C, Leeming M, Nie S, et al.
Front Pharmacol
. 2022 Oct;
13:1014804.
PMID: 36313370
Parasitic roundworms (nematodes) cause destructive diseases, and immense suffering in humans and other animals around the world. The control of these parasites relies heavily on anthelmintic therapy, but treatment failures...
18.
Maunders E, Ngu D, Ganio K, Hossain S, Lim B, Leeming M, et al.
Front Microbiol
. 2022 Jun;
13:903146.
PMID: 35685933
Acquisition of the trace-element molybdenum the high-affinity ATP-binding cassette permease ModABC is essential for respiration in anaerobic and microaerophilic environments. This study determined the X-ray crystal structures of the molybdenum-recruiting...
19.
West H, Fitzgerald J, Hopkins K, Leeming M, DiRago M, Gerostamoulos D, et al.
Drug Test Anal
. 2022 May;
14(9):1576-1586.
PMID: 35562123
Empirical data regarding dynamic alterations in illicit drug supply markets in response to the COVID-19 pandemic, including the potential for introduction of novel drug substances and/or increased poly-drug combination use...
20.
Ang C, Sacharz J, Leeming M, Nie S, Varshney S, Scott N, et al.
J Proteomics
. 2022 Jan;
254:104473.
PMID: 34990820
Co-immunoprecipitation of proteins coupled to mass spectrometry is critical for the understanding of protein interaction networks. In instances where a suitable antibody is not available, it is common to graft...