Michael Francis
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Explore the profile of Michael Francis including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Leavesley S, Johnson S, Paudel S, Knighten J, Tambe D, Francis M, et al.
Proc SPIE Int Soc Opt Eng
. 2023 Apr;
12383.
PMID: 37051186
Second messenger signals, e.g., Ca and cyclic nucleotides, orchestrate a wide range of cellular events. The methods by which second messenger signals determine specific physiological responses are complex. Recent studies...
12.
Whole-exome sequencing study identifies four novel gene loci associated with diabetic kidney disease
Pan Y, Sun X, Mi X, Huang Z, Hsu Y, Hixson J, et al.
Hum Mol Genet
. 2022 Nov;
32(6):1048-1060.
PMID: 36444934
Diabetic kidney disease (DKD) is recognized as an important public health challenge. However, its genomic mechanisms are poorly understood. To identify rare variants for DKD, we conducted a whole-exome sequencing...
13.
Rodriguez Lara F, Scruton A, Pinheiro A, Demissie S, Parva P, Charidimou A, et al.
Aging (Albany NY)
. 2022 Jul;
14(17):6844-6858.
PMID: 35852852
Background And Purpose: Cerebral small vessel disease (CSVD) increases with age and is associated with stroke and cognitive decline. Enlarged Perivascular Spaces (ePVS) is an emerging marker of CSVD, but...
14.
Taylor M, Lowery J, Choi C, Francis M
Front Physiol
. 2022 May;
13:848681.
PMID: 35492608
Endothelial dysfunction is a key feature of cardiovascular disease (CVD) including atherosclerosis. Impaired endothelial signaling leads to plaque formation, vascular wall remodeling and widespread cardiovascular dysregulation. The specific changes along...
15.
Boye C, Arpag S, Francis M, DeClemente S, West A, Heller R, et al.
Bioelectrochemistry
. 2021 Nov;
144:107981.
PMID: 34847374
Gene therapy has a wide range of applications for various types of pathologies. Viral methods of gene delivery provide high levels of gene expression but have various safety concerns. Non-viral...
16.
Boye C, Christensen K, Asadipour K, DeClemente S, Francis M, Bulysheva A
Bioelectrochemistry
. 2021 Nov;
144:107980.
PMID: 34847373
Tendon injuries are a common athletic injury that have been increasing in prevalence. While there are current clinical treatments for tendon injuries, they have relatively long recovery times and often...
17.
Boye C, Arpag S, Burcus N, Lundberg C, DeClemente S, Heller R, et al.
Bioelectrochemistry
. 2021 Aug;
142:107892.
PMID: 34371349
Damage from myocardial infarction (MI) and subsequent heart failure are serious public health concerns. Current clinical treatments and therapies to treat MI damage largely do not address the regeneration of...
18.
Bulysheva A, Heller L, Francis M, Varghese F, Boye C, Heller R
Bioelectrochemistry
. 2021 May;
140:107814.
PMID: 33962133
A novel monopolar electroporation system and methodologies were developed for in vivo electroporation intended for potential clinical applications such as gene therapy. We hypothesized that an asymmetric anode/cathode electrode applicator...
19.
Francis M, Li C, Sun Y, Zhou J, Li X, Brenna J, et al.
PLoS Genet
. 2021 Mar;
17(3):e1009431.
PMID: 33760818
Fish oil supplementation is widely used for reducing serum triglycerides (TAGs) but has mixed effects on other circulating cardiovascular biomarkers. Many genetic polymorphisms have been associated with blood lipids, including...
20.
Guha N, Nevitt S, Francis M, Bohning W, Bohning D, Sonksen P, et al.
Clin Endocrinol (Oxf)
. 2020 Nov;
94(4):551-562.
PMID: 33249593
Objective: Previous studies suggested that recombinant human IGF-1 (rhIGF-1) administration affects carbohydrate and lipid metabolism in healthy people and in people with diabetes. This study aimed to determine the effects...