Michael Fiorino
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Explore the profile of Michael Fiorino including associated specialties, affiliations and a list of published articles.
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5
Citations
39
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Recent Articles
1.
Yen J, Fiorino M, Liu Y, Paula S, Clarkson S, Quinn L, et al.
Sci Rep
. 2018 Nov;
8(1):16304.
PMID: 30389991
CRISPR/Cas9 mediated gene editing of patient-derived hematopoietic stem and progenitor cells (HSPCs) ex vivo followed by autologous transplantation of the edited HSPCs back to the patient can provide a potential...
2.
Burt J, Valente M, Agha A, Beavers K, Limback J, Fiorino M, et al.
Tomography
. 2018 Sep;
4(2):43-45.
PMID: 30206543
Prenatal ultrasonography in the early third trimester showed an unusual branching pattern of the right aortic arch. Echocardiography performed 4 h after birth showed the right aortic arch with mirror-image...
3.
Harrington P, Croghan M, Fotsch C, Frohn M, Lanman B, Pennington L, et al.
ACS Med Chem Lett
. 2014 Jun;
3(1):74-8.
PMID: 24900374
The optimization of a series of S1P1 agonists with limited activity against S1P3 is reported. A polar headgroup was used to improve the physicochemical and pharmacokinetic parameters of lead quinolinone...
4.
Pennington L, Sham K, Pickrell A, Harrington P, Frohn M, Lanman B, et al.
ACS Med Chem Lett
. 2014 Jun;
2(10):752-7.
PMID: 24900263
The sphingosine-1-phosphate-1 receptor (S1P1) and its endogenous ligand sphingosine-1-phosphate (S1P) cooperatively regulate lymphocyte trafficking from the lymphatic system. Herein, we disclose 4-methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide (8), an uncommon example of a synthetic S1P1...
5.
Pennington L, Croghan M, Sham K, Pickrell A, Harrington P, Frohn M, et al.
Bioorg Med Chem Lett
. 2011 Nov;
22(1):527-31.
PMID: 22104144
We reveal how a N-scan SAR strategy (systematic substitution of each CH group with a N atom) was employed for quinolinone-based S1P(1) agonist 5 to modulate physicochemical properties and optimize...