Michael E Todhunter
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Explore the profile of Michael E Todhunter including associated specialties, affiliations and a list of published articles.
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18
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354
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Recent Articles
1.
Sayaman R, Miyano M, Carlson E, Senapati P, Zirbes A, Shalabi S, et al.
Elife
. 2024 Nov;
13.
PMID: 39545637
Effects from aging in single cells are heterogenous, whereas at the organ- and tissue-levels aging phenotypes tend to appear as stereotypical changes. The mammary epithelium is a bilayer of two...
2.
Todhunter M, Jubair S, Verma R, Saqe R, Shen K, Duffy B
Front Artif Intell
. 2024 Oct;
7:1424012.
PMID: 39381621
Cultured meat has the potential to provide a complementary meat industry with reduced environmental, ethical, and health impacts. However, major technological challenges remain which require time-and resource-intensive research and development...
3.
Todhunter M, Miyano M, Carlson E, Hinz S, LaBarge M
Breast Cancer Res
. 2023 Jan;
25(1):6.
PMID: 36653787
Background: A challenge in human mammary epithelial cell (HMEC) culture is sustaining the representation of competing luminal, myoepithelial, and progenitor lineages over time. As cells replicate in culture, myoepithelial cells...
4.
Hinz S, Todhunter M, LaBarge M
STAR Protoc
. 2022 Mar;
3(2):101182.
PMID: 35313706
Dysregulation of the transcriptional or translational machinery can alter the stoichiometry of multiprotein complexes and occurs in natural processes such as aging. Loss of stoichiometry has been shown to alter...
5.
Shalabi S, Miyano M, Sayaman R, Lopez J, Jokela T, Todhunter M, et al.
Nat Aging
. 2022 Feb;
1(9):838-849.
PMID: 35187501
During aging in the human mammary gland, luminal epithelial cells lose lineage fidelity by expressing markers normally expressed in myoepithelial cells. We hypothesize that loss of lineage fidelity is a...
6.
Jokela T, Todhunter M, LaBarge M
Methods Mol Biol
. 2022 Jan;
2394:47-64.
PMID: 35094321
The interaction between cells and their surrounding microenvironment has a crucial role in determining cell fate. In many pathological conditions, the microenvironment drives disease progression as well as therapeutic resistance....
7.
Hinz S, Manousopoulou A, Miyano M, Sayaman R, Aguilera K, Todhunter M, et al.
iScience
. 2021 Sep;
24(9):103026.
PMID: 34522866
Age is the major risk factor in most carcinomas, yet little is known about how proteomes change with age in any human epithelium. We present comprehensive proteomes comprised of >9,000...
8.
Todhunter M, Miyano M, Moolamalla D, Filippov A, Sayaman R, LaBarge M
iScience
. 2021 Apr;
24(4):102253.
PMID: 33796842
A long-standing constraint on organoid culture is the need to add exogenous substances to provide hydrogel matrix, which limits the study of fully human or fully native organoids. This paper...
9.
Todhunter M, Sayaman R, Miyano M, LaBarge M
Curr Opin Cell Biol
. 2018 Jun;
54:121-129.
PMID: 29908481
Aging is driven by unavoidable entropic forces, physicochemical in nature, that damage the raw materials that constitute biological systems. Single cells experience and respond to stochastic physicochemical insults that occur...
10.
Hu J, Todhunter M, LaBarge M, Gartner Z
J Cell Biol
. 2017 Dec;
217(1):39-50.
PMID: 29263081
The biology of aging is challenging to study, particularly in humans. As a result, model organisms are used to approximate the physiological context of aging in humans. However, the best...