Tissue Aging: the Integration of Collective and Variant Responses of Cells to Entropic Forces over Time

Overview

Journal Curr Opin Cell Biol

Publisher Elsevier

Specialty Cell Biology

Date 2018 Jun 17

PMID 29908481

Citations 13

Authors

Michael E Todhunter

Rosalyn W Sayaman

Masaru Miyano

Mark A LaBarge

Affiliations

Soon will be listed here.

Abstract

Aging is driven by unavoidable entropic forces, physicochemical in nature, that damage the raw materials that constitute biological systems. Single cells experience and respond to stochastic physicochemical insults that occur either to the cells themselves or to their microenvironment, in a dynamic and reciprocal manner, leading to increased age-related cell-to-cell variation. We will discuss the biological mechanisms that integrate cell-to-cell variation across tissues resulting in stereotypical phenotypes of age.

Citing Articles

Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility.

Sayaman R, Miyano M, Carlson E, Senapati P, Zirbes A, Shalabi S Elife. 2024; 13.

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The Senescent Heart-"Age Doth Wither Its Infinite Variety".

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Endometrial receptivity in women of advanced age: an underrated factor in infertility.

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Single cell analysis of transcriptome and open chromatin reveals the dynamics of hair follicle stem cell aging.

Zhang C, Wang D, Dowell R, Yi R Front Aging. 2023; 4:1192149.

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Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging.

Benjamin D, Brett J, Both P, Benjamin J, Ishak H, Kang J Cell Metab. 2023; 35(3):472-486.e6.

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