Michael E Engel
Overview
Explore the profile of Michael E Engel including associated specialties, affiliations and a list of published articles.
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17
Citations
171
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Recent Articles
1.
Casey M, Call A, Thorpe A, Jette C, Engel M, Stewart R
iScience
. 2023 Jan;
26(1):105737.
PMID: 36594016
Lsd1/Kdm1a functions both as a histone demethylase enzyme and as a scaffold for assembling chromatin modifier and transcription factor complexes to regulate gene expression. The relative contributions of Lsd1's demethylase...
2.
GFI1 Cooperates with IKZF1/IKAROS to Activate Gene Expression in T-cell Acute Lymphoblastic Leukemia
Sun W, Guo J, McClellan D, Poeschla A, Bareyan D, Casey M, et al.
Mol Cancer Res
. 2022 Jan;
20(4):501-514.
PMID: 34980595
Implications: Combinatorial diversity and cooperation between DNA binding proteins and complexes assembled by them can direct context-dependent transcriptional outputs to control cell fate and may offer new insights for therapeutic...
3.
Mangum D, Meyer J, Mason C, Shams S, Maese L, Gardiner J, et al.
JAMA Oncol
. 2021 Aug;
7(10):1521-1528.
PMID: 34410295
Importance: Alterations in the IKZF1 gene drive B-cell acute lymphoblastic leukemia (B-ALL) but are not routinely used to stratify patients by risk because of inconsistent associations with outcomes. We describe...
4.
McClellan D, Casey M, Bareyan D, Lucente H, Ours C, Velinder M, et al.
Mol Cell Biol
. 2019 Apr;
39(13).
PMID: 30988160
Growth factor independence 1B (GFI1B) coordinates assembly of transcriptional repressor complexes comprised of corepressors and histone-modifying enzymes to control gene expression programs governing lineage allocation in hematopoiesis. Enforced expression of...
5.
Engel M, Datta P, Moses H
J Cell Biochem
. 2018 Jan;
72 Suppl 30-31(S30-31):111-122.
PMID: 29345828
Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of secreted factors that mobilize a complex signaling network to control cell fate by regulating proliferation, differentiation, motility, adhesion, and apoptosis....
6.
Velinder M, Singer J, Bareyan D, Meznarich J, Tracy C, Fulcher J, et al.
Biochem J
. 2017 Aug;
474(17):2951.
PMID: 28801480
No abstract available.
7.
Velinder M, Singer J, Bareyan D, Meznarich J, Tracy C, Fulcher J, et al.
Biochem J
. 2016 Aug;
473(19):3355-69.
PMID: 27480105
Proper hematopoietic cell fate decisions require co-ordinated functions of transcription factors, their associated co-regulators, and histone-modifying enzymes. Growth factor independence 1 (GFI1) is a zinc finger transcriptional repressor and master...
8.
Andrade D, Velinder M, Singer J, Maese L, Bareyan D, Nguyen H, et al.
Mol Cell Biol
. 2016 Mar;
36(10):1438-50.
PMID: 26951200
Cell fate specification requires precise coordination of transcription factors and their regulators to achieve fidelity and flexibility in lineage allocation. The transcriptional repressor growth factor independence 1 (GFI1) is comprised...
9.
Staddon J, Smock K, Schiffman J, Fluchel M, Engel M, Weyrich A, et al.
Blood Coagul Fibrinolysis
. 2015 Jul;
26(7):840-3.
PMID: 26196196
Paediatric patients with acute lymphoblastic leukaemia/lymphoma treated with pegasparaginase are at an increased risk of thrombosis. We evaluated changes in thrombin generation in the presence and absence of thrombomodulin using...
10.
Fadul J, Bell R, Hoffman L, Beckerle M, Engel M, Lessnick S
Genes Cancer
. 2015 May;
6(3-4):129-43.
PMID: 26000096
In Ewing sarcoma, NKX2-2 is a critical activated target of the oncogenic transcription factor EWS/FLI that is required for transformation. However, its biological function in this malignancy is unknown. Here...