Scott W Hiebert
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Explore the profile of Scott W Hiebert including associated specialties, affiliations and a list of published articles.
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89
Citations
3221
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Recent Articles
1.
Elmas A, Layden H, Ellis J, Bartlett L, Zhao X, Kawabata-Iwakawa R, et al.
bioRxiv
. 2024 Nov;
PMID: 39484404
Cancer cells are heterogeneous, each harboring distinct molecular aberrations and are dependent on different genes for their survival and proliferation. While successful targeted therapies have been developed based on driver...
2.
Short S, Brown R, Chen Z, Pilat J, McElligott B, Meenderink L, et al.
Cell Death Differ
. 2024 Jul;
31(9):1170-1183.
PMID: 39048708
Undifferentiated intestinal stem cells (ISCs) are crucial for maintaining homeostasis and resolving injury. Lgr5+ cells in the crypt base constantly divide, pushing daughter cells upward along the crypt axis where...
3.
Layden H, Ellis J, Bomber M, Bartlett L, Hiebert S, Stengel K
Cell Genom
. 2024 Apr;
4(4):100537.
PMID: 38604128
Transcriptional dysregulation is a hallmark of diffuse large B cell lymphoma (DLBCL), as transcriptional regulators are frequently mutated. However, our mechanistic understanding of how normal transcriptional programs are co-opted in...
4.
Kelly R, Stengel K, Chandru A, Johnson L, Hiebert S, Cowley S
Genome Res
. 2024 Jan;
34(1):34-46.
PMID: 38290976
Histone acetylation is a dynamic modification regulated by the opposing actions of histone acetyltransferases (HATs) and histone deacetylases (HDACs). Deacetylation of histone tails results in chromatin tightening, and therefore, HDACs...
5.
Hiebert S
Mol Cell
. 2024 Jan;
84(1):5-7.
PMID: 38181763
While reviewers' recommendations can strengthen a manuscript, responding to their concerns can be a tricky and frustrating process for authors. For our special issue on stress, Molecular Cell speaks with...
6.
Layden H, Johnson A, Hiebert S
Trends Cancer
. 2023 Sep;
10(1):65-75.
PMID: 37722945
Transcriptional dysregulation is a key step in oncogenesis, but our understanding of transcriptional control has relied on genetic approaches that are slow and allow for compensation. Chemical-genetic approaches have shortened...
7.
Sroka M, Skopelitis D, Vermunt M, Preall J, El Demerdash O, de Almeida L, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(36):e2303859120.
PMID: 37639593
Recurrent chromosomal rearrangements found in rhabdomyosarcoma (RMS) produce the PAX3-FOXO1 fusion protein, which is an oncogenic driver and a dependency in this disease. One important function of PAX3-FOXO1 is to...
8.
Bomber M, Wang J, Liu Q, Barnett K, Layden H, Hodges E, et al.
Mol Cell
. 2023 Jan;
83(4):507-522.e6.
PMID: 36630954
Genetic models suggested that SMARCA5 was required for DNA-templated events including transcription, DNA replication, and DNA repair. We engineered a degron tag into the endogenous alleles of SMARCA5, a catalytic...
9.
Zhang S, Wang J, Liu Q, McDonald W, Bomber M, Layden H, et al.
Mol Cell
. 2022 Nov;
82(23):4428-4442.e7.
PMID: 36395771
Transcriptional control is a highly dynamic process that changes rapidly in response to various cellular and extracellular cues, making it difficult to define the mechanism of transcription factor function using...
10.
Brown R, Jacobse J, Anant S, Blunt K, Chen B, Vega P, et al.
JCI Insight
. 2022 May;
7(10).
PMID: 35503250
Aberrant epithelial differentiation and regeneration contribute to colon pathologies, including inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Myeloid translocation gene 16 (MTG16, also known as CBFA2T3) is a transcriptional...