Michael E Doche
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Explore the profile of Michael E Doche including associated specialties, affiliations and a list of published articles.
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9
Citations
190
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Recent Articles
1.
Tavakoli N, Fong E, Coleman A, Huang Y, Bigger M, Doche M, et al.
NPJ Syst Biol Appl
. 2025 Jan;
11(1):12.
PMID: 39875420
Cancer-associated fibroblasts (CAFs) play a key role in metabolic reprogramming and are well-established contributors to drug resistance in colorectal cancer (CRC). To exploit this metabolic crosstalk, we integrated a systems...
2.
Ha D, Shin W, Liu Z, Doche M, Lau R, Leli N, et al.
Cell Biosci
. 2024 Sep;
14(1):115.
PMID: 39238058
Background: Despite recent therapeutic advances, combating cancer resistance remains a formidable challenge. The 78-kilodalton glucose-regulated protein (GRP78), a key stress-inducible endoplasmic reticulum (ER) chaperone, plays a crucial role in both...
3.
Tavakoli N, Fong E, Coleman A, Huang Y, Bigger M, Doche M, et al.
bioRxiv
. 2024 Jun;
PMID: 38826317
Cancer-associated fibroblasts (CAFs) play a key role in metabolic reprogramming and are well-established contributors to drug resistance in colorectal cancer (CRC). To exploit this metabolic crosstalk, we integrated a systems...
4.
Cote J, Vander P, Ellis M, Cline J, Svezhova N, Doche M, et al.
J Cell Sci
. 2022 Jan;
135(3).
PMID: 35019135
The adapter protein SH2B1 is recruited to neurotrophin receptors, including TrkB (also known as NTRK2), the receptor for brain-derived neurotrophic factor (BDNF). Herein, we demonstrate that the four alternatively spliced...
5.
Garvey C, Lau R, Sanchez A, Sun R, Fong E, Doche M, et al.
Cancers (Basel)
. 2020 Jun;
12(6).
PMID: 32481658
Targeted agents have improved the efficacy of chemotherapy for cancer patients, however, there remains a lack of understanding of how these therapies affect the unsuspecting bystanders of the stromal microenvironment....
6.
Joe R, Flores A, Doche M, Cline J, Clutter E, Vander P, et al.
Mol Cell Biol
. 2017 Dec;
38(6).
PMID: 29229648
The scaffold protein SH2B1, a major regulator of body weight, is recruited to the receptors of multiple cytokines and growth factors, including nerve growth factor (NGF). The β isoform but...
7.
Ma Z, Shiao S, Yoshida E, Swartwood S, Huang F, Doche M, et al.
Diagn Pathol
. 2017 Sep;
12(1):69.
PMID: 28923066
Background: Immune cell infiltrates (ICI) of tumors are scored by pathologists around tumor glands. To obtain a better understanding of the immune infiltrate, individual immune cell types, their activation states...
8.
Ehrhardt N, Doche M, Chen S, Mao H, Walsh M, Bedoya C, et al.
Hum Mol Genet
. 2017 Apr;
26(14):2719-2731.
PMID: 28449094
The human transmembrane 6 superfamily member 2 (TM6SF2) gene has been implicated in plasma lipoprotein metabolism, alcoholic and non-alcoholic fatty liver disease and myocardial infarction in multiple genome-wide association studies....
9.
Pearce L, Joe R, Doche M, Su H, Keogh J, Henning E, et al.
Endocrinology
. 2014 Jun;
155(9):3219-26.
PMID: 24971614
We have previously reported rare variants in sarcoma (Src) homology 2 (SH2) B adaptor protein 1 (SH2B1) in individuals with obesity, insulin resistance, and maladaptive behavior. Here, we identify 4...
10.
Doche M, Bochukova E, Su H, Pearce L, Keogh J, Henning E, et al.
J Clin Invest
. 2012 Nov;
122(12):4732-6.
PMID: 23160192
Src homology 2 B adapter protein 1 (SH2B1) modulates signaling by a variety of ligands that bind to receptor tyrosine kinases or JAK-associated cytokine receptors, including leptin, insulin, growth hormone...