Michael Demetriou
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Explore the profile of Michael Demetriou including associated specialties, affiliations and a list of published articles.
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40
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1784
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Recent Articles
1.
Mkhikian H, Zhou R, Saryan H, Sanchez C, Balakrishnan A, Dang J, et al.
J Immunol
. 2024 Sep;
213(9):1329-1337.
PMID: 39269653
N-glycan branching is a potent and multifaceted negative regulator of proinflammatory T cell and B cell function. By promoting multivalent galectin-glycoprotein lattice formation at the cell surface, branching regulates clustering...
2.
Sy M, Newton B, Pawling J, Hayama K, Cordon A, Yu Z, et al.
J Neuroinflammation
. 2023 Sep;
20(1):209.
PMID: 37705084
Background: In the demyelinating disease multiple sclerosis (MS), chronic-active brain inflammation, remyelination failure and neurodegeneration remain major issues despite immunotherapy. While B cell depletion and blockade/sequestration of T and B...
3.
Annapragada A, Sikora A, Marathe H, Liu S, Demetriou M, Fong L, et al.
J Natl Cancer Inst
. 2023 Aug;
115(11):1262-1270.
PMID: 37572314
The Immuno-Oncology Translational Network (IOTN) was established in 2018 as part of the Cancer Moonshot. In 2022, President Joe Biden set new goals to reduce the cancer death rate by...
4.
Mkhikian H, Demetriou M
Aging (Albany NY)
. 2022 Aug;
14(15):5964-5965.
PMID: 35963641
No abstract available.
5.
Mkhikian H, Hayama K, Khachikyan K, Li C, Zhou R, Pawling J, et al.
Nat Aging
. 2022 May;
2(3):231-242.
PMID: 35528547
Impaired T cell immunity with aging increases mortality from infectious disease. The branching of Asparagine-linked glycans is a critical negative regulator of T cell immunity. Here we show that branching...
6.
McKitrick T, Ackerman M, Anthony R, Bennett C, Demetriou M, Hudalla G, et al.
Front Microbiol
. 2021 Oct;
12:731008.
PMID: 34646251
Advances in experimental capabilities in the glycosciences offer expanding opportunities for discovery in the broad areas of immunology and microbiology. These two disciplines overlap when microbial infection stimulates host immune...
7.
Brandt A, Sy M, Bellmann-Strobl J, Newton B, Pawling J, Zimmermann H, et al.
JAMA Neurol
. 2021 May;
78(7):842-852.
PMID: 33970182
Importance: N-glycan branching modulates cell surface receptor availability, and its deficiency in mice promotes inflammatory demyelination, reduced myelination, and neurodegeneration. N-acetylglucosamine (GlcNAc) is a rate-limiting substrate for N-glycan branching, but,...
8.
Sy M, Brandt A, Lee S, Newton B, Pawling J, Golzar A, et al.
J Biol Chem
. 2021 Jan;
295(51):17413-17424.
PMID: 33453988
Myelination plays an important role in cognitive development and in demyelinating diseases like multiple sclerosis (MS), where failure of remyelination promotes permanent neuro-axonal damage. Modification of cell surface receptors with...
9.
Backer-Koduah P, Infante-Duarte C, Ivaldi F, Uccelli A, Bellmann-Strobl J, Wernecke K, et al.
Ann Clin Transl Neurol
. 2020 Aug;
7(9):1628-1641.
PMID: 32830462
Objective: To investigate the effect of cholecalciferol (vitamin D3) supplementation on peripheral immune cell frequency and N-glycan branching in patients with relapsing-remitting multiple sclerosis (RRMS). Methods: Exploratory analysis of high-dose...
10.
Mortales C, Lee S, Manousadjian A, Hayama K, Demetriou M
iScience
. 2020 Aug;
23(8):101380.
PMID: 32745987
B cell depletion potently reduces episodes of inflammatory demyelination in multiple sclerosis (MS), predominantly through loss of innate rather than adaptive immunity. However, molecular mechanisms controlling innate versus adaptive B...