Michael Demetriou
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Explore the profile of Michael Demetriou including associated specialties, affiliations and a list of published articles.
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40
Citations
1784
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Recent Articles
11.
Mortales C, Lee S, Demetriou M
J Immunol
. 2020 Jun;
205(3):630-636.
PMID: 32591389
Galectins have been implicated in inhibiting BCR signaling in mature B cells but promoting pre-BCR signaling during early development. Galectins bind to branched -glycans attached to cell surface glycoproteins to...
12.
Annapragada A, Sikora A, Bollard C, Conejo-Garcia J, Cruz C, Demehri S, et al.
J Immunother Cancer
. 2020 Jun;
8(1).
PMID: 32554617
Despite regulatory approval of several immune-based treatments for cancer in the past decade, a number of barriers remain to be addressed in order to fully harness the therapeutic potential of...
13.
Lee S, Li C, Mortales C, Pawling J, Dennis J, Grigorian A, et al.
PLoS One
. 2019 Mar;
14(3):e0214253.
PMID: 30913278
N-acetylglucosamine (GlcNAc) branching of Asn (N)-linked glycans inhibits pro-inflammatory T cell responses and models of autoimmune diseases such as Multiple Sclerosis (MS). Metabolism controls N-glycan branching in T cells by...
14.
Yale A, Nourse J, Lee K, Ahmed S, Arulmoli J, Jiang A, et al.
Stem Cell Reports
. 2018 Sep;
11(4):869-882.
PMID: 30197120
Understanding the cellular properties controlling neural stem and progenitor cell (NSPC) fate choice will improve their therapeutic potential. The electrophysiological measure whole-cell membrane capacitance reflects fate bias in the neural...
15.
Tran M, Mkhikian H, Sy M, Perez-Alvarez I, Demetriou M
Transfus Apher Sci
. 2018 Jun;
57(3):418-420.
PMID: 29891220
Hashimoto's encephalopathy (HE) is a presumed autoimmune disorder associated with anti-thyroid autoantibodies and signs and symptoms of encephalopathy. A sub-type of HE is associated with cerebellar dysfunction and ataxia. Immunosuppressive...
16.
Araujo L, Khim P, Mkhikian H, Mortales C, Demetriou M
Elife
. 2017 Jan;
6.
PMID: 28059703
Rapidly proliferating cells switch from oxidative phosphorylation to aerobic glycolysis plus glutaminolysis, markedly increasing glucose and glutamine catabolism. Although Otto Warburg first described aerobic glycolysis in cancer cells >90 years...
17.
Mkhikian H, Mortales C, Zhou R, Khachikyan K, Wu G, Haslam S, et al.
Elife
. 2016 Jun;
5.
PMID: 27269286
Essential biological systems employ self-correcting mechanisms to maintain cellular homeostasis. Mammalian cell function is dynamically regulated by the interaction of cell surface galectins with branched N-glycans. Here we report that...
18.
Yu Z, Demetriou M, Gillen D
Genet Epidemiol
. 2015 Jun;
39(6):446-55.
PMID: 26095143
Despite the successful discovery of hundreds of variants for complex human traits using genome-wide association studies, the degree to which genes and environmental risk factors jointly affect disease risk is...
19.
Zhou R, Mkhikian H, Grigorian A, Hong A, Chen D, Arakelyan A, et al.
Nat Immunol
. 2014 Sep;
15(11):1038-45.
PMID: 25263124
Positive selection of diverse yet self-tolerant thymocytes is vital to immunity and requires a limited degree of T cell antigen receptor (TCR) signaling in response to self peptide-major histocompatibility complexes...
20.
Williams R, Ma X, Schott R, Mohammad N, Ho C, Li C, et al.
PLoS One
. 2014 Jan;
9(1):e86088.
PMID: 24475074
Protein N-glycosylation is found in all domains of life and has a conserved role in glycoprotein folding and stability. In animals, glycoproteins transit through the Golgi where the N-glycans are...