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Michael D Sheets

Explore the profile of Michael D Sheets including associated specialties, affiliations and a list of published articles. Areas
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Articles 32
Citations 450
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Recent Articles
1.
Mclaughlin M, Sun M, Beames T, Steward A, Theisen J, Chung H, et al.
Dev Dyn . 2022 Dec; 252(4):483-494. PMID: 36495293
Background: Frem1 has been linked to human face shape variation, dysmorphology, and malformation, but little is known about its regulation and biological role in facial development. Results: During midfacial morphogenesis...
2.
Kanzler C, Donohue M, Dowdle M, Sheets M
Dev Biol . 2022 Oct; 492:133-138. PMID: 36270327
BioID is a proximity labeling strategy whose goal is to identify in vivo protein-protein interactions. The central components of this strategy are modified biotin ligase enzymes that promiscuously add biotin...
3.
Dowdle M, Kanzler C, Harder C, Moffet S, Walker M, Sheets M
Front Cell Dev Biol . 2022 Sep; 10:981696. PMID: 36158189
Bicaudal-C (Bicc1) is an evolutionarily conserved RNA binding protein that functions in a regulatory capacity in a variety of contexts. It was originally identified as a genetic locus in that...
4.
Maerker M, Getwan M, Dowdle M, McSheene J, Gonzalez V, Pelliccia J, et al.
Nat Commun . 2021 Sep; 12(1):5482. PMID: 34531379
Rotating cilia at the vertebrate left-right organizer (LRO) generate an asymmetric leftward flow, which is sensed by cells at the left LRO margin. Ciliary activity of the calcium channel Pkd2...
5.
Dowdle M, Park S, Blaser Imboden S, Fox C, Houston D, Sheets M
Development . 2019 Apr; 146(10). PMID: 31023875
Bicaudal-C (Bicc1) is a conserved RNA-binding protein that represses the translation of selected mRNAs to control development. In embryos, Bicc1 binds and represses specific maternal mRNAs to control anterior-posterior cell...
6.
Sheets M
Methods Mol Biol . 2019 Feb; 1920:33-39. PMID: 30737684
The earliest steps of animal development depend upon posttranscriptional events that drive the embryonic cell cycle and guide cell fate decisions. The analysis of post-transcriptional regulatory events has relied upon...
7.
Slosarek E, Schuh A, Pustova I, Johnson A, Bird J, Johnson M, et al.
Cell Rep . 2018 Aug; 24(9):2248-2260. PMID: 30157421
Length-dependent axonopathy of the corticospinal tract causes lower limb spasticity and is characteristic of several neurological disorders, including hereditary spastic paraplegia (HSP) and amyotrophic lateral sclerosis. Mutations in Trk-fused gene...
8.
Fink D, Sun M, Heyne G, Everson J, Chung H, Park S, et al.
Cell Signal . 2017 Dec; 44:1-9. PMID: 29284139
Sonic Hedgehog (Shh) signaling plays key regulatory roles in embryonic development and postnatal homeostasis and repair. Modulation of the Shh pathway is known to cause malformations and malignancies associated with...
9.
Dowdle M, Blaser Imboden S, Park S, Ryder S, Sheets M
J Vis Exp . 2017 Aug; (125). PMID: 28784977
Native polyacrylamide gel electrophoresis is a fundamental tool of molecular biology that has been used extensively for the biochemical analysis of RNA-protein interactions. These interactions have been traditionally analyzed with...
10.
Sheets M, Fox C, Dowdle M, Blaser S, Chung A, Park S
Adv Exp Med Biol . 2016 Dec; 953:49-82. PMID: 27975270
The selective translation of maternal mRNAs encoding cell-fate determinants drives the earliest decisions of embryogenesis that establish the vertebrate body plan. This chapter will discuss studies in Xenopus laevis that...