Michael D Conkright
Overview
Explore the profile of Michael D Conkright including associated specialties, affiliations and a list of published articles.
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14
Citations
1813
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Recent Articles
1.
Bruno N, Nwachukwu J, Hughes D, Srinivasan S, Hawkins R, Sturgill D, et al.
FASEB J
. 2021 Nov;
35(12):e21999.
PMID: 34748223
The Creb-Regulated Transcriptional Coactivator (Crtc) family of transcriptional coregulators drive Creb1-mediated transcription effects on metabolism in many tissues, but the in vivo effects of Crtc2/Creb1 transcription on skeletal muscle metabolism...
2.
Niopek K, Ekim Ustunel B, Seitz S, Sakurai M, Zota A, Mattijssen F, et al.
Cell Rep
. 2017 Aug;
20(6):1422-1434.
PMID: 28793265
Increased pro-inflammatory signaling is a hallmark of metabolic dysfunction in obesity and diabetes. Although both inflammatory and energy substrate handling processes represent critical layers of metabolic control, their molecular integration...
3.
Amelio A, Fallahi M, Schaub F, Zhang M, Lawani M, Alperstein A, et al.
Proc Natl Acad Sci U S A
. 2014 Jul;
111(32):E3260-8.
PMID: 25071166
Chimeric oncoproteins created by chromosomal translocations are among the most common genetic mutations associated with tumorigenesis. Malignant mucoepidermoid salivary gland tumors, as well as a growing number of solid epithelial-derived...
4.
Nwachukwu J, Srinivasan S, Bruno N, Parent A, Hughes T, Pollock J, et al.
Elife
. 2014 Apr;
3:e02057.
PMID: 24771768
Resveratrol has beneficial effects on aging, inflammation and metabolism, which are thought to result from activation of the lysine deacetylase, sirtuin 1 (SIRT1), the cAMP pathway, or AMP-activated protein kinase....
5.
Bruno N, Kelly K, Hawkins R, Bramah-Lawani M, Amelio A, Nwachukwu J, et al.
EMBO J
. 2014 Mar;
33(9):1027-43.
PMID: 24674967
During the stress response to intense exercise, the sympathetic nervous system (SNS) induces rapid catabolism of energy reserves through the release of catecholamines and subsequent activation of protein kinase A...
6.
Hollander J, Im H, Amelio A, Kocerha J, Bali P, Lu Q, et al.
Nature
. 2010 Jul;
466(7303):197-202.
PMID: 20613834
Cocaine addiction is characterized by a gradual loss of control over drug use, but the molecular mechanisms regulating vulnerability to this process remain unclear. Here we report that microRNA-212 (miR-212)...
7.
Amelio A, Caputi M, Conkright M
EMBO J
. 2009 Aug;
28(18):2733-47.
PMID: 19644446
The CREB regulated transcription co-activators (CRTCs) regulate many biological processes by integrating and converting environmental inputs into transcriptional responses. Although the mechanisms by which CRTCs sense cellular signals are characterized,...
8.
Altarejos J, Goebel N, Conkright M, Inoue H, Xie J, Arias C, et al.
Nat Med
. 2008 Sep;
14(10):1112-7.
PMID: 18758446
The adipocyte-derived hormone leptin maintains energy balance by acting on hypothalamic leptin receptors (Leprs) that act on the signal transducer and activator of transcription 3 (Stat3). Although disruption of Lepr-Stat3...
9.
Amelio A, Miraglia L, Conkright J, Mercer B, Batalov S, Cavett V, et al.
Proc Natl Acad Sci U S A
. 2007 Dec;
104(51):20314-9.
PMID: 18077367
Signal transduction pathways often use a transcriptional component to mediate adaptive cellular responses. Coactivator proteins function prominently in these pathways as the conduit to the basic transcriptional machinery. Here we...
10.
Conkright M, Montminy M
Trends Cell Biol
. 2005 Aug;
15(9):457-9.
PMID: 16084096
The transcription factor cAMP response-element binding protein (CREB) participates in a diverse array of cellular processes, including survival, proliferation and glucose metabolism. A new report by Shankar et al. shows...