Michael Costanzo
Overview
Explore the profile of Michael Costanzo including associated specialties, affiliations and a list of published articles.
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105
Citations
7232
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Recent Articles
1.
Suresh H, Bonneil E, Albert B, Dominique C, Costanzo M, Pons C, et al.
Mol Cell
. 2024 Jun;
84(12):2337-2352.e9.
PMID: 38870935
Ribosome assembly requires precise coordination between the production and assembly of ribosomal components. Mutations in ribosomal proteins that inhibit the assembly process or ribosome function are often associated with ribosomopathies,...
2.
Lin K, Chang Y, Billmann M, Ward H, Le K, Hassan A, et al.
Sci Rep
. 2024 Jan;
14(1):2508.
PMID: 38291084
Current approaches to define chemical-genetic interactions (CGIs) in human cell lines are resource-intensive. We designed a scalable chemical-genetic screening platform by generating a DNA damage response (DDR)-focused custom sgRNA library...
3.
Varland S, Silva R, Kjosas I, Faustino A, Bogaert A, Billmann M, et al.
Nat Commun
. 2023 Oct;
14(1):6774.
PMID: 37891180
Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic...
4.
Mishra P, Au W, Castineira P, Ali N, Stanton J, Boeckmann L, et al.
Mol Biol Cell
. 2023 Jul;
34(10):ar99.
PMID: 37436802
Centromere () identity is specified epigenetically by specialized nucleosomes containing evolutionarily conserved -specific histone H3 variant CENP-A (Cse4 in , CENP-A in humans), which is essential for faithful chromosome segregation....
5.
Suresh H, Bonneil E, Albert B, Dominique C, Costanzo M, Pons C, et al.
bioRxiv
. 2023 May;
PMID: 37205480
Ribosome assembly requires precise coordination between the production and assembly of ribosomal components. Mutations in ribosomal proteins that inhibit the assembly process or ribosome function are often associated with Ribosomopathies,...
6.
Billmann M, Ward H, Aregger M, Costanzo M, Andrews B, Boone C, et al.
Cell Syst
. 2023 May;
14(5):418-422.e2.
PMID: 37201508
CRISPR screens are used extensively to systematically interrogate the phenotype-to-genotype problem. In contrast to early CRISPR screens, which defined core cell fitness genes, most current efforts now aim to identify...
7.
Conti M, Ghizzoni J, Gil-Bona A, Wang W, Costanzo M, Li R, et al.
PLoS Genet
. 2022 Aug;
18(8):e1010349.
PMID: 36037231
A network of transcription factors (TFs) coordinates transcription with cell cycle events in eukaryotes. Most TFs in the network are phosphorylated by cyclin-dependent kinase (CDK), which limits their activities during...
8.
Nsamba E, Bera A, Costanzo M, Boone C, Gupta M
J Cell Biol
. 2021 Nov;
220(12).
PMID: 34739032
Microtubules are dynamic cytoskeleton filaments that are essential for a wide range of cellular processes. They are polymerized from tubulin, a heterodimer of α- and β-subunits. Most eukaryotic organisms express...
9.
Rahman M, Billmann M, Costanzo M, Aregger M, Tong A, Chan K, et al.
Mol Syst Biol
. 2021 May;
17(5):e10013.
PMID: 34018332
We present FLEX (Functional evaluation of experimental perturbations), a pipeline that leverages several functional annotation resources to establish reference standards for benchmarking human genome-wide CRISPR screen data and methods for...
10.
Kong K, Fischer B, Meurer M, Kats I, Li Z, Ruhle F, et al.
Mol Cell
. 2021 May;
81(11):2460-2476.e11.
PMID: 33974913
Selective protein degradation by the ubiquitin-proteasome system (UPS) is involved in all cellular processes. However, the substrates and specificity of most UPS components are not well understood. Here we systematically...