Michael Costanzo
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Explore the profile of Michael Costanzo including associated specialties, affiliations and a list of published articles.
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105
Citations
7232
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Recent Articles
11.
Costanzo M, Hou J, Messier V, Nelson J, Rahman M, VanderSluis B, et al.
Science
. 2021 May;
372(6542).
PMID: 33958448
Phenotypes associated with genetic variants can be altered by interactions with other genetic variants (GxG), with the environment (GxE), or both (GxGxE). Yeast genetic interactions have been mapped on a...
12.
Eisenstatt J, Ohkuni K, Au W, Preston O, Gliford L, Suva E, et al.
Genetics
. 2021 Mar;
218(1).
PMID: 33751052
Mislocalization of the centromeric histone H3 variant (Cse4 in budding yeast, CID in flies, CENP-A in humans) to noncentromeric regions contributes to chromosomal instability (CIN) in yeast, fly, and human...
13.
Kuzmin E, Rahman M, VanderSluis B, Costanzo M, Myers C, Andrews B, et al.
Nat Protoc
. 2021 Jan;
16(2):1219-1250.
PMID: 33462440
Systematic complex genetic interaction studies have provided insight into high-order functional redundancies and genetic network wiring of the cell. Here, we describe a method for screening and quantifying trigenic interactions...
14.
Aregger M, Lawson K, Billmann M, Costanzo M, Tong A, Chan K, et al.
Nat Metab
. 2020 Jul;
2(6):499-513.
PMID: 32694731
The de novo synthesis of fatty acids has emerged as a therapeutic target for various diseases, including cancer. Because cancer cells are intrinsically buffered to combat metabolic stress, it is...
15.
Kuzmin E, VanderSluis B, Nguyen Ba A, Wang W, Koch E, Usaj M, et al.
Science
. 2020 Jun;
368(6498).
PMID: 32586993
Whole-genome duplication has played a central role in the genome evolution of many organisms, including the human genome. Most duplicated genes are eliminated, and factors that influence the retention of...
16.
Eisenstatt J, Boeckmann L, Au W, Garcia V, Bursch L, Ocampo J, et al.
G3 (Bethesda)
. 2020 Apr;
10(6):2057-2068.
PMID: 32295767
The evolutionarily conserved centromeric histone H3 variant (Cse4 in budding yeast, CENP-A in humans) is essential for faithful chromosome segregation. Mislocalization of CENP-A to non-centromeric chromatin contributes to chromosomal instability...
17.
Au W, Zhang T, Mishra P, Eisenstatt J, Walker R, Ocampo J, et al.
PLoS Genet
. 2020 Feb;
16(2):e1008597.
PMID: 32032354
Restricting the localization of the histone H3 variant CENP-A (Cse4 in yeast, CID in flies) to centromeres is essential for faithful chromosome segregation. Mislocalization of CENP-A leads to chromosomal instability...
18.
Fang G, Wang W, Paunic V, Heydari H, Costanzo M, Liu X, et al.
Nat Commun
. 2019 Sep;
10(1):4274.
PMID: 31537791
Genetic interactions have been reported to underlie phenotypes in a variety of systems, but the extent to which they contribute to complex disease in humans remains unclear. In principle, genome-wide...
19.
Corcoles-Saez I, Ferat J, Costanzo M, Boone C, Cha R
Microb Cell
. 2019 Jun;
6(6):286-294.
PMID: 31172013
Ribonucleotide reductase (RNR) is an essential holoenzyme required for synthesis of dNTPs. The genome encodes for two catalytic subunits, Rnr1 and Rnr3. While Rnr1 is required for DNA replication and...
20.
Costanzo M, Kuzmin E, van Leeuwen J, Mair B, Moffat J, Boone C, et al.
Cell
. 2019 Mar;
177(1):85-100.
PMID: 30901552
Genetic interactions identify combinations of genetic variants that impinge on phenotype. With whole-genome sequence information available for thousands of individuals within a species, a major outstanding issue concerns the interpretation...