Michael Closser
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Explore the profile of Michael Closser including associated specialties, affiliations and a list of published articles.
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10
Citations
354
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Recent Articles
1.
Dorrity T, Shin H, Wiegand K, Aruda J, Closser M, Jung E, et al.
Sci Immunol
. 2023 Oct;
8(88):eadg2979.
PMID: 37862432
Loss of RNA homeostasis underlies numerous neurodegenerative and neuroinflammatory diseases. However, the molecular mechanisms that trigger neuroinflammation are poorly understood. Viral double-stranded RNA (dsRNA) triggers innate immune responses when sensed...
2.
Patel T, Hammelman J, Aziz S, Jang S, Closser M, Michaels T, et al.
Nat Commun
. 2022 Sep;
13(1):5427.
PMID: 36109497
Neurons born in the embryo can undergo a protracted period of maturation lasting well into postnatal life. How gene expression changes are regulated during maturation and whether they can be...
3.
Hammelman J, Patel T, Closser M, Wichterle H, Gifford D
Nat Methods
. 2022 Jun;
19(7):812-822.
PMID: 35710610
Transcription factor over-expression is a proven method for reprogramming cells to a desired cell type for regenerative medicine and therapeutic discovery. However, a general method for the identification of reprogramming...
4.
Closser M, Guo Y, Wang P, Patel T, Jang S, Hammelman J, et al.
Neuron
. 2021 Nov;
110(1):70-85.e6.
PMID: 34727520
Proper assembly and function of the nervous system requires the generation of a uniquely diverse population of neurons expressing a cell-type-specific combination of effector genes that collectively define neuronal morphology,...
5.
Guo Y, Krismer K, Closser M, Wichterle H, Gifford D
Nucleic Acids Res
. 2019 Apr;
47(6):e35.
PMID: 30953075
Chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) is a method for the genome-wide de novo discovery of chromatin interactions. Existing computational methods typically fail to detect weak or dynamic...
6.
Rhee H, Closser M, Guo Y, Bashkirova E, Tan G, Gifford D, et al.
Neuron
. 2016 Dec;
92(6):1252-1265.
PMID: 27939581
Generic spinal motor neuron identity is established by cooperative binding of programming transcription factors (TFs), Isl1 and Lhx3, to motor-neuron-specific enhancers. How expression of effector genes is maintained following downregulation...
7.
Reeder C, Closser M, Poh H, Sandhu K, Wichterle H, Gifford D
PLoS One
. 2015 May;
10(5):e0122420.
PMID: 25970635
RNA Polymerase II ChIA-PET data has revealed enhancers that are active in a profiled cell type and the genes that the enhancers regulate through chromatin interactions. The most commonly used...
8.
Leung W, Shaffer C, Reed L, Smith S, Barshop W, Dirkes W, et al.
G3 (Bethesda)
. 2015 Mar;
5(5):719-40.
PMID: 25740935
The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties...
9.
Mazzoni E, Mahony S, Closser M, Morrison C, Nedelec S, Williams D, et al.
Nat Neurosci
. 2013 Jul;
16(9):1219-27.
PMID: 23872598
Efficient transcriptional programming promises to open new frontiers in regenerative medicine. However, mechanisms by which programming factors transform cell fate are unknown, preventing more rational selection of factors to generate...
10.
Mazzoni E, Mahony S, Iacovino M, Morrison C, Mountoufaris G, Closser M, et al.
Nat Methods
. 2011 Nov;
8(12):1056-8.
PMID: 22081127
The study of developmentally regulated transcription factors by chromatin immunoprecipitation and deep sequencing (ChIP-seq) faces two major obstacles: availability of ChIP-grade antibodies and access to sufficient number of cells. We...