Michael Chvanov
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Explore the profile of Michael Chvanov including associated specialties, affiliations and a list of published articles.
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27
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932
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Recent Articles
1.
Chvanov M, Voronina S, Jefferson M, Mayer U, Sutton R, Criddle D, et al.
Autophagy
. 2024 Aug;
21(1):210-222.
PMID: 39216469
The WD40 domain (WDD) of ATG16L1 plays a pivotal role in non-canonical autophagy. This study examined the role of recently identified LAP-like non-canonical autophagy (LNCA) in acute pancreatitis. LNCA involves...
2.
Voronina S, Chvanov M, De Faveri F, Mayer U, Wileman T, Criddle D, et al.
Cells
. 2022 Aug;
11(16).
PMID: 36010591
Recent studies have highlighted the importance of autophagy and particularly non-canonical autophagy in the development and progression of acute pancreatitis (a frequent disease with considerable morbidity and significant mortality). An...
3.
Ouyang Y, Wen L, Armstrong J, Chvanov M, Latawiec D, Cai W, et al.
Cells
. 2021 Apr;
10(5).
PMID: 33925729
Acute pancreatitis (AP) is a severe and potentially fatal disease caused predominantly by alcohol excess and gallstones, which lacks a specific therapy. The role of Receptor-Interacting Protein Kinase 1 (RIPK1),...
4.
Chvanov M, Voronina S, Zhang X, Telnova S, Chard R, Ouyang Y, et al.
Cells
. 2020 Jun;
9(6).
PMID: 32516955
Acute pancreatitis is a frequent disease that lacks specific drug treatment. Unravelling the molecular mechanisms of acute pancreatitis is essential for the development of new therapeutics. Several inducers of acute...
5.
Ma X, Jin T, Han C, Shi N, Liang G, Wen Y, et al.
J Ethnopharmacol
. 2020 Apr;
257:112861.
PMID: 32315735
Ethnopharmacological Relevance: Dachengqi decoction (DCQD) belongs to a family of purgative herbal formulas widely used in China for the treatment of acute pancreatitis (AP). AP is a prevalent digestive disease...
6.
De Faveri F, Chvanov M, Voronina S, Moore D, Pollock L, Haynes L, et al.
Autophagy
. 2019 Oct;
16(7):1314-1331.
PMID: 31651224
Abbreviations: AP: acute pancreatitis; CCK: cholecystokinin; CLEM: correlative light and electron microscopy; DPI: diphenyleneiodonium; EV: endocytic vacuole; LAP: LC3-associate phagocytosis; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; PACs: pancreatic acinar...
7.
Zhang X, Jin T, Shi N, Yao L, Yang X, Han C, et al.
Front Physiol
. 2019 Jan;
9:1922.
PMID: 30697165
Pancreatic acinar cells require high rates of amino acid uptake for digestive enzyme synthesis, but excessive concentrations can trigger acute pancreatitis (AP) by mechanisms that are not well understood. We...
8.
Yao L, Cheng C, Yang X, Han C, Du D, Liu T, et al.
Pancreatology
. 2019 Jan;
19(2):209-216.
PMID: 30611702
Ethyl pyruvate (EP) has been shown to improve outcomes from multiple organ dysfunction syndrome (MODS) in experimental animal models of critical illness. This review aimed to summarise in vitro and...
9.
Chvanov M, De Faveri F, Moore D, Sherwood M, Awais M, Voronina S, et al.
J Physiol
. 2018 May;
596(13):2547-2564.
PMID: 29717784
Key Points: Giant trypsin-containing endocytic vacuoles are formed in pancreatic acinar cells stimulated with inducers of acute pancreatitis. F-actin envelops endocytic vacuoles and regulates their properties. Endocytic vacuoles can rupture...
10.
Armstrong J, Cash N, Ouyang Y, Morton J, Chvanov M, Latawiec D, et al.
J Biol Chem
. 2018 Apr;
293(21):8032-8047.
PMID: 29626097
Mitochondrial dysfunction lies at the core of acute pancreatitis (AP). Diverse AP stimuli induce Ca-dependent formation of the mitochondrial permeability transition pore (MPTP), a solute channel modulated by cyclophilin D...