Michael C Summers
Overview
Explore the profile of Michael C Summers including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
18
Citations
393
Followers
0
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Related Specialties
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Recent Articles
1.
McCoy R, Summers M, McCollin A, Ottolini C, Ahuja K, Handyside A
Genome Med
. 2023 Oct;
15(1):77.
PMID: 37779206
Background: The high incidence of aneuploidy in early human development, arising either from errors in meiosis or postzygotic mitosis, is the primary cause of pregnancy loss, miscarriage, and stillbirth following...
2.
Handyside A, McCollin A, Summers M, Ottolini C
Prenat Diagn
. 2020 Aug;
41(5):525-535.
PMID: 32833230
Preimplantation genetic testing for aneuploidy (PGT-A) by copy number analysis is now widely used to select euploid embryos for transfer. Whole or partial chromosome aneuploidy can arise in meiosis, predominantly...
3.
McCollin A, Swann R, Summers M, Handyside A, Ottolini C
Eur J Med Genet
. 2019 Apr;
63(2):103651.
PMID: 30995534
Despite improvements in culture conditions and laboratory techniques still only about 50% of human embryos reach the blastocyst stage of development in vitro. While many factors influence embryo development, aberrant...
4.
Rosenwaks Z, Handyside A, Fiorentino F, Gleicher N, Paulson R, Schattman G, et al.
Fertil Steril
. 2018 Aug;
110(3):353-361.
PMID: 30098682
No abstract available.
5.
Ottolini C, Kitchen J, Xanthopoulou L, Gordon T, Summers M, Handyside A
Sci Rep
. 2017 Aug;
7(1):9744.
PMID: 28851957
Following in vitro fertilisation (IVF), only about half of normally fertilised human embryos develop beyond cleavage and morula stages to form a blastocyst in vitro. Although many human embryos are...
6.
Ottolini C, Rogers S, Sage K, Summers M, Capalbo A, Griffin D, et al.
Reprod Biomed Online
. 2015 Sep;
31(6):776-82.
PMID: 26380865
Blastocyst biopsy is now widely used for both preimplantation genetic screening (PGS) and preimplantation genetic diagnosis (PGD). Although this approach yields good results, variable embryo quality and rates of development...
7.
Ottolini C, Newnham L, Capalbo A, Natesan S, Joshi H, Cimadomo D, et al.
Nat Genet
. 2015 May;
47(7):727-735.
PMID: 25985139
Crossover recombination reshuffles genes and prevents errors in segregation that lead to extra or missing chromosomes (aneuploidy) in human eggs, a major cause of pregnancy failure and congenital disorders. Here...
8.
Natesan S, Handyside A, Thornhill A, Ottolini C, Sage K, Summers M, et al.
Reprod Biomed Online
. 2014 Aug;
29(5):600-5.
PMID: 25154779
Preimplantation genetic diagnosis (PGD) for monogenic disorders has the drawback of time and cost associated with tailoring a specific test for each couple, disorder, or both. The inability of any...
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