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Michael Basso

Explore the profile of Michael Basso including associated specialties, affiliations and a list of published articles. Areas
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Articles 22
Citations 231
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Recent Articles
1.
Chirinos J, Zhao L, Reese-Petersen A, Cohen J, Genovese F, Richards A, et al.
NEJM Evid . 2023 Aug; 1(10). PMID: 37645406
Background: Endotrophin, a collagen type VI-derived peptide, mediates metabolic dysregulation, inflammation, and fibrosis in animal models, but has not been studied in human heart failure (HF). Methods: We examined the...
2.
Javaheri A, Diab A, Zhao L, Qian C, Cohen J, Zamani P, et al.
Circ Heart Fail . 2022 Sep; 15(9):e009693. PMID: 36126144
Background: The TOPCAT trial (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial) suggested clinical benefits of spironolactone treatment among patients with heart failure with preserved ejection...
3.
Vidula M, Orlenko A, Zhao L, Salvador L, Small A, Horton E, et al.
Eur J Heart Fail . 2021 Oct; 23(12):2021-2032. PMID: 34632675
Aims: Enhanced risk stratification of patients with aortic stenosis (AS) is necessary to identify patients at high risk for adverse outcomes, and may allow for better management of patient subgroups...
4.
Tora G, Kim S, Pi Z, Johnson J, Jiang J, Phillips M, et al.
J Med Chem . 2020 Jan; 63(4):1660-1670. PMID: 31990537
Endothelial lipase (EL) hydrolyzes phospholipids in high-density lipoprotein (HDL) resulting in reduction in plasma HDL levels. Studies with murine transgenic, KO, or loss-of-function variants strongly suggest that inhibition of EL...
5.
Prenner S, Kumar A, Zhao L, Cvijic M, Basso M, Spires T, et al.
Am J Cardiol . 2019 Dec; 125(4):575-582. PMID: 31843232
Little data are available regarding the determinants and prognostic significance of serum albumin in Heart Failure with Preserved Ejection Fraction (HFpEF). We sought to examine the phenotypic correlates of albumin...
6.
Kim S, Johnson J, Jiang J, Parkhurst B, Phillips M, Pi Z, et al.
Bioorg Med Chem Lett . 2019 Jul; 29(17):2525. PMID: 31353296
No abstract available.
7.
Kim S, Johnson J, Jiang J, Parkhurst B, Phillips M, Pi Z, et al.
Bioorg Med Chem Lett . 2019 Jun; 29(15):1918-1921. PMID: 31176700
A low level of high density lipoprotein (HDL) is an independent risk factor for cardiovascular disease. HDL reduces inflammation and plays a central role in reverse cholesterol transport, where cholesterol...
8.
Johnson J, Tora G, Pi Z, Phillips M, Yin X, Yang R, et al.
ACS Med Chem Lett . 2019 Jan; 9(12):1263-1268. PMID: 30613337
Endothelial lipase (EL) selectively metabolizes high density lipoprotein (HDL) particles. Inhibition of EL has been shown to increase HDL concentration in preclinical animal models and was targeted as a potential...
9.
Wurtz N, Viet A, Shaw S, Dilger A, Valente M, Khan J, et al.
ACS Med Chem Lett . 2019 Jan; 9(12):1175-1180. PMID: 30613322
Myeloperoxidase (MPO) generates reactive oxygen species that potentially contribute to many chronic inflammatory diseases. A recently reported triazolopyrimidine MPO inhibitor was optimized to improve acid stability and remove methyl guanine...
10.
Onorato J, Xu C, Chen X, Rose A, Generaux C, Lentz K, et al.
Anal Biochem . 2019 Jan; 568:41-50. PMID: 30605634
Apelin, the endogenous ligand for the APJ receptor, has generated interest due to its beneficial effects on the cardiovascular system. Synthesized as a 77 amino acid preproprotein, apelin is post-translationally...