Leonard P Adam
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Explore the profile of Leonard P Adam including associated specialties, affiliations and a list of published articles.
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25
Citations
139
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Recent Articles
1.
Liu M, Cook E, Dai Y, Ehlert E, du Plessis F, Lubelski J, et al.
Mol Ther Methods Clin Dev
. 2025 Mar;
33(1):101411.
PMID: 40027261
Safely achieving therapeutic expression levels with adeno-associated virus (AAV) gene therapy is a significant challenge for treating the large muscle mass in humans. Non-human primates (NHPs) provide a more accurate...
2.
Hu Z, Sitkoff D, Glunz P, Zou Y, Wang C, Muckelbauer J, et al.
Bioorg Med Chem Lett
. 2023 Apr;
88:129304.
PMID: 37119973
Derivatives of lactam, cyclic urea and carbamate were explored as aniline amide replacements in a series of phthalazinone-based ROCK inhibitors. Potent ROCK2 inhibitors such as 22 were identified with excellent...
3.
Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model
Raja A, Wakimoto H, DeLaughter D, Reichart D, Gorham J, Conner D, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(28):e2204174119.
PMID: 35787042
Myocardial fibrosis is a key pathologic feature of hypertrophic cardiomyopathy (HCM). However, the fibrotic pathways activated by HCM-causing sarcomere protein gene mutations are poorly defined. Because lysophosphatidic acid is a...
4.
Hu Z, Wang C, Sitkoff D, Cheadle N, Xu S, Muckelbauer J, et al.
Bioorg Med Chem Lett
. 2020 Aug;
30(21):127474.
PMID: 32805407
A novel series of 5H-chromeno[3,4-c]pyridine, 6H-isochromeno[3,4-c]pyridine and 6H-isochromeno[4,3-d]pyrimidine derivatives as dual ROCK1 and ROCK2 inhibitors is described. Optimization led to compounds with sub-nanomolar inhibitory affinity for both kinases and excellent...
5.
Hu Z, Wang C, Glunz P, Li J, Cheadle N, Chen A, et al.
Bioorg Med Chem Lett
. 2020 Aug;
30(21):127495.
PMID: 32798651
Structure-activity relationship optimization on a series of phenylpyrazole amides led to the identification of a dual ROCK1 and ROCK2 inhibitor (25) which demonstrated good potency, kinome selectivity and favorable pharmacokinetic...
6.
Sleczka B, Levesque P, Adam L, Olah T, Shipkova P
Anal Biochem
. 2020 May;
602:113766.
PMID: 32389692
The S100A1 protein is a target of interest for the treatment of heart failure as it has been previously reported to be depleted in failing cardiomyocytes. A gene therapy approach...
7.
Tora G, Kim S, Pi Z, Johnson J, Jiang J, Phillips M, et al.
J Med Chem
. 2020 Jan;
63(4):1660-1670.
PMID: 31990537
Endothelial lipase (EL) hydrolyzes phospholipids in high-density lipoprotein (HDL) resulting in reduction in plasma HDL levels. Studies with murine transgenic, KO, or loss-of-function variants strongly suggest that inhibition of EL...
8.
Meng W, Adam L, Behnia K, Zhao L, Yang R, Kopcho L, et al.
Bioorg Med Chem Lett
. 2019 Sep;
29(20):126673.
PMID: 31519373
A series of benzothiazoles with a cyano group was synthesized and evaluated as endothelial lipase (EL) inhibitors for the potential treatment of cardiovascular diseases. Efforts to reduce molecular weight and...
9.
Kim S, Johnson J, Jiang J, Parkhurst B, Phillips M, Pi Z, et al.
Bioorg Med Chem Lett
. 2019 Jul;
29(17):2525.
PMID: 31353296
No abstract available.
10.
Finlay H, Jiang J, Rampulla R, Salvati M, Qiao J, Wang T, et al.
ACS Med Chem Lett
. 2019 Jun;
10(6):911-916.
PMID: 31223447
Lead optimization of the diphenylpyridylethanamine (DPPE) and triphenylethanamine (TPE) series of CETP inhibitors to improve their pharmaceutical profile is described. Polar groups at the -terminus position in the DPPE series...