Hartmut Derendorf
Overview
Explore the profile of Hartmut Derendorf including associated specialties, affiliations and a list of published articles.
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Articles
225
Citations
4085
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Recent Articles
1.
Bulman Z, Wicha S, Nielsen E, Lenhard J, Nation R, Theuretzbacher U, et al.
Lancet Microbe
. 2022 Jul;
3(10):e795-e802.
PMID: 35777386
Antibiotic resistance presents an incessant threat to our drug armamentarium that necessitates novel approaches to therapy. Over the past several decades, investigation of pharmacokinetic and pharmacodynamic (PKPD) principles has substantially...
2.
Schroepf S, Burau D, Muench H, Derendorf H, Zeitlinger M, Genzel-Boroviczeny O, et al.
Int J Antimicrob Agents
. 2021 Jul;
58(4):106405.
PMID: 34289402
Objectives: Septic infants/neonates need effective antibiotic exposure, but dosing recommendations are challenging as the pharmacokinetics in this age are highly variable. For vancomycin, which is used as a standard treatment,...
3.
Khaowroongrueng V, Jadhav S, Syed M, Akbar M, Gertz M, Otteneder M, et al.
J Pharm Sci
. 2021 Apr;
110(8):3061-3068.
PMID: 33819461
R7072 is a fully human monoclonal antibody (mAb) exerting anti-tumor activity via blockade of insulin like growth factor 1 receptor. The tumoral interstitial concentrations are anticipated to be better surrogates...
4.
Rayner C, Smith P, Andes D, Andrews K, Derendorf H, Friberg L, et al.
Clin Pharmacol Ther
. 2021 Feb;
109(4):867-891.
PMID: 33555032
Model-informed drug development (MIDD) has a long and rich history in infectious diseases. This review describes foundational principles of translational anti-infective pharmacology, including choice of appropriate measures of exposure and...
5.
Chellian R, Wilks I, Levin B, Xue S, Behnood-Rod A, Wilson R, et al.
Psychopharmacology (Berl)
. 2021 Jan;
238(3):845-855.
PMID: 33410984
Rationale: Systemic administration of the tobacco smoke constituent nicotine stimulates brain reward function in rats. However, it is unknown if the inhalation of tobacco smoke affects brain reward function. Objectives:...
6.
Darby S, Sanchez L, Mallicote M, House A, Plummer C, Nadruz V, et al.
Equine Vet J
. 2020 Dec;
54(1):145-152.
PMID: 33369767
Background: Creeping indigo (Indigofera spicata) toxicosis is an emerging problem among horses in Florida and bordering states. Objectives: To quantify the putative toxins l-indospicine (IND) and 3-nitropropionic acid (NPA) in...
7.
Pai S, Othman A, Rusch L, Masters J, Greene D, Rogge M, et al.
J Clin Pharmacol
. 2020 Dec;
61(3):277-279.
PMID: 33274473
No abstract available.
8.
Derendorf H, Peloquin C
Clin Pharmacokinet
. 2020 Aug;
59(9):1063.
PMID: 32789605
No abstract available.
9.
do Nascimento S, Nascimento M, de Araujo L, de Oliveira F, do Carmo Vieira M, Duarte-Almeida J, et al.
Curr Drug Metab
. 2020 May;
21(4):281-290.
PMID: 32394829
Background: Maytenus ilicifolia is a Brazilian popular medicine commonly used to treat ulcer and gastritis. Despite the absence of toxicity regarding its consumption, possible interactions when co-administrated with conventional drugs,...
10.
Derendorf H
Int J Antimicrob Agents
. 2020 May;
55(6):106007.
PMID: 32389720
A recent report identified significant reductions or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin. The present communication discusses some common pharmacokinetic properties of...