Michael B Mumphrey
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Explore the profile of Michael B Mumphrey including associated specialties, affiliations and a list of published articles.
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19
Citations
414
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Recent Articles
1.
Kaur A, Surnilla A, Zaitouna A, Mumphrey M, Basrur V, Grigorova I, et al.
J Immunol
. 2023 Sep;
211(9):1298-1307.
PMID: 37737643
The extreme polymorphisms of HLA class I proteins result in structural variations in their peptide binding sites to achieve diversity in Ag presentation. External factors could independently constrict or alter...
2.
Mumphrey M, Hosseini N, Parolia A, Geng J, Zou W, Raghavan M, et al.
Cell Rep
. 2023 Aug;
42(8):112965.
PMID: 37597185
Disruption of antigen presentation via loss of major histocompatibility complex (MHC) expression is a strategy whereby cancer cells escape immune surveillance and develop resistance to immunotherapy. Here, we develop the...
3.
Kaur A, Surnilla A, Zaitouna A, Basrur V, Mumphrey M, Grigorova I, et al.
bioRxiv
. 2023 Mar;
PMID: 36909546
Activation of CD8 T cells against pathogens and cancers involves the recognition of antigenic peptides bound to human leukocyte antigen (HLA) class-I proteins. Peptide binding to HLA class I proteins...
4.
Faramia J, Hao Z, Mumphrey M, Townsend R, Miard S, Carreau A, et al.
Cell Rep Med
. 2021 May;
2(4):100248.
PMID: 33948578
Insulin-like growth factor-binding protein (IGFBP)-2 is a circulating biomarker of cardiometabolic health. Here, we report that circulating IGFBP-2 concentrations robustly increase after different bariatric procedures in humans, reaching higher levels...
5.
Mumphrey M, Hao Z, Townsend R, Qualls-Creekmore E, Yu S, Lutz T, et al.
Sci Rep
. 2019 May;
9(1):7881.
PMID: 31133715
Gastric bypass surgery is the most effective treatment and is often the only option for subjects with severe obesity. However, investigation of critical molecular mechanisms involved has been hindered by...
6.
Boland B, Mumphrey M, Hao Z, Townsend R, Gill B, Oldham S, et al.
Mol Metab
. 2019 May;
25:64-72.
PMID: 31126840
Objective: Understanding the mechanisms underlying the remarkable beneficial effects of gastric bypass surgery is important for the development of non-surgical therapies or less invasive surgeries in the fight against obesity...
7.
Boland B, Mumphrey M, Hao Z, Gill B, Townsend R, Yu S, et al.
Nutrients
. 2019 Mar;
11(3).
PMID: 30857366
Background/goals: The gut hormone peptide YY (PYY) secreted from intestinal L-cells has been implicated in the mechanisms of satiation via Y2-receptor (Y2R) signaling in the brain and periphery and is...
8.
Patkar P, Hao Z, Mumphrey M, Townsend R, Berthoud H, Shin A
Int J Obes (Lond)
. 2019 Feb;
43(11):2143-2150.
PMID: 30718818
Objectives: Dieting often fails because weight loss triggers strong counter-regulatory biological responses such as increased hunger and hypometabolism that are thought to be critically dependent on the master fuel sensor...
9.
Peiris M, Aktar R, Raynel S, Hao Z, Mumphrey M, Berthoud H, et al.
Nutrients
. 2018 Oct;
10(10).
PMID: 30336615
Background: Nutrient-sensing receptors located on enteroendocrine (EEC) cells modulate appetite via detection of luminal contents. Colonic 'tasting' of luminal contents may influence changes to appetite observed in obesity and after...
10.
Hao Z, Townsend R, Mumphrey M, Gettys T, Yu S, Munzberg H, et al.
Obes Surg
. 2018 May;
28(10):3227-3236.
PMID: 29770924
Background And Purpose: Roux-en-Y gastric bypass surgery (RYGB) remains one of the most effective treatments for obesity and type 2 diabetes. Despite this, the mechanisms through which it acts are...