Michael B Dinkins
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Explore the profile of Michael B Dinkins including associated specialties, affiliations and a list of published articles.
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13
Citations
993
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Recent Articles
1.
Elsherbini A, Kirov A, Dinkins M, Wang G, Qin H, Zhu Z, et al.
Acta Neuropathol Commun
. 2020 Apr;
8(1):60.
PMID: 32345374
Amyloid-β (Aβ) associates with extracellular vesicles termed exosomes. It is not clear whether and how exosomes modulate Aβ neurotoxicity in Alzheimer's disease (AD). We show here that brain tissue and...
2.
Zhong L, Jiang X, Zhu Z, Qin H, Dinkins M, Kong J, et al.
Glia
. 2018 Nov;
67(3):498-511.
PMID: 30484906
Accumulating evidence indicates that neuroinflammation contributes to the pathogenesis and exacerbation of neurodegenerative disorders, such as Alzheimer's disease (AD). Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid that regulates many pathophysiological...
3.
Zhong L, Kong J, Dinkins M, Leanhart S, Zhu Z, Spassieva S, et al.
J Lipid Res
. 2018 Mar;
59(5):795-804.
PMID: 29567647
Sphingolipids are key signaling lipids in cancer. Genome-wide studies have identified neutral SMase-2 (nSMase2), an enzyme generating ceramide from SM, as a potential repressor for hepatocellular carcinoma. However, little is...
4.
Kong J, Zhu Z, Itokazu Y, Wang G, Dinkins M, Zhong L, et al.
J Lipid Res
. 2018 Jan;
59(3):488-506.
PMID: 29321137
We reported that amyloid β peptide (Aβ) activated neutral SMase 2 (nSMase2), thereby increasing the concentration of the sphingolipid ceramide in astrocytes. Here, we show that Aβ induced mitochondrial fragmentation...
5.
Helwa I, Cai J, Drewry M, Zimmerman A, Dinkins M, Khaled M, et al.
PLoS One
. 2017 Jan;
12(1):e0170628.
PMID: 28114422
Exosomes play a role in cell-to-cell signaling and serve as possible biomarkers. Isolating exosomes with reliable quality and substantial concentration is a major challenge. Our purpose is to compare the...
6.
Dinkins M, Wang G, Bieberich E
J Alzheimers Dis
. 2016 Sep;
60(3):757-768.
PMID: 27662306
Extracellular vesicles (EVs), particularly exosomes, have emerged in the last 10 years as a new player in the progression of Alzheimer's disease (AD) with high potential for being useful as...
7.
Dinkins M, Enasko J, Hernandez C, Wang G, Kong J, Helwa I, et al.
J Neurosci
. 2016 Aug;
36(33):8653-67.
PMID: 27535912
Unlabelled: Recent evidence implicates exosomes in the aggregation of Aβ and spreading of tau in Alzheimer's disease. In neural cells, exosome formation can be blocked by inhibition or silencing of...
8.
Kong J, He Q, Wang G, Dasgupta S, Dinkins M, Zhu G, et al.
Int J Cancer
. 2015 Apr;
137(7):1610-20.
PMID: 25833198
Many breast cancer cells acquire multidrug resistance (MDR) mediated by ABC transporters such as breast cancer resistance protein (BCRP/ABCG2). Here we show that incubation of human breast cancer MDA-MB-231 cells...
9.
Dinkins M, Dasgupta S, Wang G, Zhu G, He Q, Kong J, et al.
J Alzheimers Dis
. 2015 Feb;
46(1):55-61.
PMID: 25720409
We present evidence that 5XFAD Alzheimer's disease model mice develop an age-dependent increase in antibodies against ceramide, suggesting involvement of autoimmunity against ceramide in Alzheimer's disease pathology. To test this,...
10.
Dinkins M, Dasgupta S, Wang G, Zhu G, Bieberich E
Neurobiol Aging
. 2014 Mar;
35(8):1792-800.
PMID: 24650793
We present evidence here that exosomes stimulate aggregation of amyloid beta (Aβ)1-42 in vitro and in vivo and interfere with uptake of Aβ by primary cultured astrocytes and microglia in ...