Michael Albers
Overview
Explore the profile of Michael Albers including associated specialties, affiliations and a list of published articles.
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21
Citations
336
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Recent Articles
1.
Xue X, De Leon-Tabaldo A, Luna-Roman R, Castro G, Albers M, Schoetens F, et al.
Sci Rep
. 2022 Apr;
12(1):5740.
PMID: 35388049
No abstract available.
2.
Xue X, De Leon-Tabaldo A, Luna-Roman R, Castro G, Albers M, Schoetens F, et al.
Sci Rep
. 2021 May;
11(1):11066.
PMID: 34040108
The nuclear receptor retinoid-related orphan receptor gamma t (RORγt) plays a critical role in driving Th17 cell differentiation and expansion, as well as IL-17 production in innate and adaptive immune...
3.
Steeneck C, Kinzel O, Anderhub S, Hornberger M, Pinto S, Morschhaeuser B, et al.
Bioorg Med Chem Lett
. 2020 Dec;
33:127744.
PMID: 33333163
Since the advent of antibody checkpoint inhibitors as highly efficient drugs for cancer treatment, the development of immunomodulating small molecules in oncology has gained great attention. Drug candidates targeting IDO1,...
4.
Kinzel O, Steeneck C, Anderhub S, Hornberger M, Pinto S, Morschhaeuser B, et al.
Bioorg Med Chem Lett
. 2020 Dec;
33:127738.
PMID: 33316404
Through structural modification of an oxalamide derived chemotype, a novel class of highly potent, orally bioavailable IDO1-specific inhibitors was identified. Representative compound 18 inhibited human IDO1 with IC values of...
5.
Gege C, Albers M, Kinzel O, Kleymann G, Schluter T, Steeneck C, et al.
Bioorg Med Chem Lett
. 2020 Apr;
30(12):127205.
PMID: 32336498
The nuclear receptor retinoic acid receptor-related orphan receptor gamma t (RORγt) is a transcription factor that drives Th17 cell differentiation and IL-17 production in both innate and adaptive immune cells....
6.
Steeneck C, Gege C, Kinzel O, Albers M, Kleymann G, Schluter T, et al.
Bioorg Med Chem Lett
. 2020 Apr;
30(12):127174.
PMID: 32334912
Starting from previously identified thiazole-2-carboxamides exemplified by compound 1/6, two new series of RORγt inverse agonists with significantly improved aqueous solubility, ADME parameters and oral PK properties were discovered. These...
7.
Tanis V, Venkatesan H, Cummings M, Albers M, Barbay J, Herman K, et al.
Bioorg Med Chem Lett
. 2019 Apr;
29(12):1463-1470.
PMID: 31010722
We have previously reported the syntheses of a series of 3,6-disubstituted quinolines as modulators of the retinoic acid receptor-related orphan receptor gamma t (RORγt). These molecules are potent binders but...
8.
Gege C, Cummings M, Albers M, Kinzel O, Kleymann G, Schluter T, et al.
Bioorg Med Chem Lett
. 2018 Apr;
28(9):1446-1455.
PMID: 29631962
The nuclear receptor retinoic acid receptor-related orphan receptor gamma t (RORγt) is a transcription factor that drives Th17 cell differentiation and IL-17 production in both innate and adaptive immune cells....
9.
Voglis S, Moos S, Kloos L, Wanke F, Zayoud M, Pelczar P, et al.
Sci Rep
. 2018 Mar;
8(1):5085.
PMID: 29572462
IL-22 is a potent pro-inflammatory cytokine upregulated in psoriasis and in other inflammatory diseases. The function of IL-22 is regulated by the soluble scavenging receptor, IL-22 binding protein (IL-22BP or...
10.
Xue X, Soroosh P, De Leon-Tabaldo A, Luna-Roman R, Sablad M, Rozenkrants N, et al.
Sci Rep
. 2016 Dec;
6:37977.
PMID: 27905482
The IL-23/IL-17 pathway is implicated in autoimmune diseases, particularly psoriasis, where biologics targeting IL-23 and IL-17 have shown significant clinical efficacy. Retinoid-related orphan nuclear receptor gamma t (RORγt) is required...