Michael A Pearen
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Explore the profile of Michael A Pearen including associated specialties, affiliations and a list of published articles.
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19
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560
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Recent Articles
1.
Fuller O, McLennan E, Egan C, Perera N, Terry L, Pyun J, et al.
iScience
. 2025 Feb;
28(2):111752.
PMID: 39898049
Exercise improves cognitive function in Alzheimer's disease (AD) via mechanism that are not fully clear. Here, we first examined the effect of voluntary exercise training (VET) on energy metabolism and...
2.
Curren B, Ahmed T, Rashid R, Sebina I, Sikder M, Howard D, et al.
Cell Rep
. 2024 Nov;
43(11):114974.
PMID: 39535919
A poor maternal diet during pregnancy predisposes the infant to severe lower respiratory tract infections (sLRIs), which, in turn, increases childhood asthma risk; however, the underlying mechanisms remain poorly understood....
3.
Fernandez-Rojo M, Pearen M, Burgess A, Ikonomopoulou M, Hoang-Le D, Genz B, et al.
Sci Signal
. 2024 Apr;
17(830):eade4335.
PMID: 38564492
Serum ferritin concentrations increase during hepatic inflammation and correlate with the severity of chronic liver disease. Here, we report a molecular mechanism whereby the heavy subunit of ferritin (FTH) contributes...
4.
Loo C, Pearen M, Ramm G
Int J Mol Sci
. 2021 Sep;
22(18).
PMID: 34576017
The Hedgehog (HH) signalling pathway is one of the major pathways controlling cell differentiation and proliferation during human development. This pathway is complex, with HH function influenced by inhibitors, promotors,...
5.
Pearen M, Lim H, Gratte F, Fernandez-Rojo M, Nawaratna S, Gobert G, et al.
J Vis Exp
. 2020 Apr;
(157).
PMID: 32225165
Understanding the mechanisms of liver injury, hepatic fibrosis, and cirrhosis that underlie chronic liver diseases (i.e., viral hepatitis, non-alcoholic fatty liver disease, metabolic liver disease, and liver cancer) requires experimental...
6.
Pearen M, Muscat G
Exerc Sport Sci Rev
. 2018 Jan;
46(2):97-104.
PMID: 29346164
Exercise induces various physical and metabolic changes in skeletal muscle that adaptively reprograms this tissue to current physiological and environmental demands. Underlying these changes are broad modifications to gene expression....
7.
Lung and liver growth and retinoic acid status in human fetuses with congenital diaphragmatic hernia
Loo C, Pearen M, Pereira T, Perry-Keene J, Payton D, Ramm G
Early Hum Dev
. 2017 Nov;
116:17-23.
PMID: 29096166
Background: Abnormal retinoic acid (RA) signalling is considered a major cause of congenital diaphragmatic hernia (CDH). Pulmonary hypoplasia and pulmonary hypertension are the major causes of morbidity and mortality in...
8.
Pozniak K, Pearen M, Pereira T, Kramer C, Kalita-de Croft P, Nawaratna S, et al.
Am J Pathol
. 2017 Sep;
187(12):2744-2757.
PMID: 28935574
Cystic fibrosis liver disease (CFLD) in children causes progressive fibrosis leading to biliary cirrhosis; however, its cause(s) and early pathogenesis are unclear. We hypothesized that a bile acid-induced ductular reaction...
9.
Goode J, Pearen M, Tuong Z, Wang S, Oh T, Shao E, et al.
Mol Endocrinol
. 2016 May;
30(6):660-76.
PMID: 27144290
Skeletal muscle remodels metabolic capacity, contractile and exercise phenotype in response to physiological demands. This adaptive remodeling response to physical activity can ameliorate/prevent diseases associated with poor diet and lifestyle....
10.
Lau P, Tuong Z, Wang S, Fitzsimmons R, Goode J, Thomas G, et al.
Am J Physiol Endocrinol Metab
. 2014 Nov;
308(2):E159-71.
PMID: 25424999
The Rar-related orphan receptor-α (Rorα) is a nuclear receptor that regulates adiposity and is a potential regulator of energy homeostasis. We have demonstrated that the Rorα-deficient staggerer (sg/sg) mice display...