Merja H Voutilainen
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Explore the profile of Merja H Voutilainen including associated specialties, affiliations and a list of published articles.
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36
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1182
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Recent Articles
1.
Scordino M, Stepanova P, Srinivasan V, Pham D, Eriksson O, Lalowski M, et al.
Front Mol Neurosci
. 2024 Oct;
17:1473058.
PMID: 39359687
Canopy Homolog 2 (CNPY2) is an endoplasmic reticulum (ER) localized protein belonging to the CNPY gene family. We show here that CNPY2 is protective against ER stress induced by tunicamycin...
2.
Nam J, Richie C, Harvey B, Voutilainen M
Sci Rep
. 2024 Jul;
14(1):16487.
PMID: 39019902
Cerebral dopamine neurotrophic factor (CDNF) and its close structural relative, mesencephalic astrocyte-derived neurotrophic factor (MANF), are proteins with neurotrophic properties. CDNF protects and restores the function of dopamine (DA) neurons...
3.
Singh A, Panhelainen A, Reunanen S, Luk K, Voutilainen M
Eur J Neurosci
. 2023 Dec;
59(1):132-153.
PMID: 38072889
The existent pre-clinical models of Parkinson's disease do not simultaneously recapitulate severe degeneration of dopamine neurons and the occurrence of alpha-synuclein (aSyn) aggregation in one study system. In this study,...
4.
Singh A, Panhelainen A, Voutilainen M
Neurosci Lett
. 2023 Oct;
816:137510.
PMID: 37802418
Parkinson's disease (PD) is characterized by the loss of nigrostriatal dopamine (DA) neurons and the presence of alpha-synuclein (αSyn)-positive Lewy body (LB) pathology. In this study, we attempted to recapitulate...
5.
De Lorenzo F, Luningschror P, Nam J, Beckett L, Pilotto F, Galli E, et al.
Brain
. 2023 Mar;
146(9):3783-3799.
PMID: 36928391
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that affects motor neurons in the spinal cord, brainstem and motor cortex, leading to paralysis and eventually to death within 3-5 years...
6.
Kovaleva V, Yu L, Ivanova L, Shpironok O, Nam J, Eesmaa A, et al.
Cell Rep
. 2023 Feb;
42(2):112066.
PMID: 36739529
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-located protein with cytoprotective effects in neurons and pancreatic β cells in vitro and in models of neurodegeneration and diabetes in ...
7.
Nam J, Koppinen T, Voutilainen M
Front Cell Neurosci
. 2021 Jul;
15:640084.
PMID: 34305531
Multiple sclerosis (MS) is a progressive autoimmune disease characterized by T-cell mediated demyelination in central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is a widely used disease model of MS....
8.
Renko J, Mahato A, Visnapuu T, Valkonen K, Karelson M, Voutilainen M, et al.
J Parkinsons Dis
. 2021 May;
11(3):1023-1046.
PMID: 34024778
Background: Parkinson's disease (PD) is a progressive neurological disorder where loss of dopamine neurons in the substantia nigra and dopamine depletion in the striatum cause characteristic motor symptoms. Currently, no...
9.
Albert K, Raymundo D, Panhelainen A, Eesmaa A, Shvachiy L, Araujo G, et al.
Mol Ther
. 2021 May;
29(9):2821-2840.
PMID: 33940158
A molecular hallmark in Parkinson's disease (PD) pathogenesis are α-synuclein aggregates. Cerebral dopamine neurotrophic factor (CDNF) is an atypical growth factor that is mostly resident in the endoplasmic reticulum but...
10.
Renko J, Voutilainen M, Visnapuu T, Sidorova Y, Saarma M, Tuominen R
Front Neurol Neurosci Res
. 2021 Jan;
1:100004.
PMID: 33479704
Parkinson's disease (PD) is an incurable neurodegenerative disorder affecting up to 10 million people in the world. Diagnostic motor symptoms of PD appear as a result of progressive degeneration and...