Merita Murtola
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Explore the profile of Merita Murtola including associated specialties, affiliations and a list of published articles.
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20
Citations
103
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Recent Articles
1.
Luige O, Karale K, Bose P, Bollmark M, Tedebark U, Murtola M, et al.
RSC Adv
. 2022 Apr;
12(9):5398-5406.
PMID: 35425588
The development of Zn-dependent dimethyl-dppz-PNA conjugates (PNAzymes) as efficient site-specific artificial ribonucleases enables rapid sequence-specific degradation of clinically relevant RNA target sequences, but the significance of the RNA/PNAzyme sequence and...
2.
Honcharenko D, Rocha C, Lundin K, Maity J, Milton S, Tedebark U, et al.
Nucleic Acid Ther
. 2022 Mar;
32(3):221-233.
PMID: 35238623
2'--(-(Aminoethyl)carbamoyl)methyl (2'--AECM)-modified oligonucleotides (ONs) and their mixmers with 2'--methyl oligonucleotides (2'-OMe ONs) with phosphodiester linkers as well as with partial and full phosphorothioate (PS) inclusion were synthesized and functionally evaluated...
3.
Luige O, Bose P, Stulz R, Steunenberg P, Brun O, Andersson S, et al.
Chem Commun (Camb)
. 2021 Sep;
57(83):10911-10914.
PMID: 34590632
We present Zn-dependent dimethyl-dipyridophenazine PNA conjugates as efficient RNA cleaving artificial enzymes. These PNAzymes display site-specific RNA cleavage with 10 minute half-lives and cleave clinically relevant RNA models.
4.
Luige O, Murtola M, Ghidini A, Stromberg R
Molecules
. 2019 Feb;
24(4).
PMID: 30769777
Peptide nucleic acid (PNA)-neocuproine conjugates have been shown to efficiently catalyse the cleavage of RNA target sequences in the presence of Cu ions in a site-specific manner. These artificial enzymes...
5.
Murtola M, Ghidini A, Virta P, Stromberg R
Molecules
. 2017 Nov;
22(11).
PMID: 29109368
In this report, we investigate the efficiency and selectivity of a Zn-dependent peptide nucleic acid-based artificial ribonuclease (PNAzyme) that cleaves RNA target sequences. The target RNAs are varied to form...
6.
Gahtory D, Murtola M, Smulders M, Wennekes T, Zuilhof H, Stromberg R, et al.
Org Biomol Chem
. 2017 Aug;
15(32):6710-6714.
PMID: 28766647
In this report, we show how a convenient on-resin copper-click functionalization of azido-functionalized peptide nucleic acids (PNAs) allows various PNA-based detection strategies. Firstly, a thiazole orange (TO) clicked PNA probe...
7.
Tahtinen V, Granqvist L, Murtola M, Stromberg R, Virta P
Chemistry
. 2017 Apr;
23(29):7113-7124.
PMID: 28370485
Triplex-forming peptide nucleic acids (TFPNAs) were targeted to double-helical regions of F-labeled RNA hairpin models (a UA-rich duplex with a hexaethylene glycol (heg) loop and a microRNA model, miR-215). In...
8.
Ghidini A, Bergquist H, Murtola M, Punga T, Zain R, Stromberg R
Org Biomol Chem
. 2016 May;
14(23):5210-3.
PMID: 27203783
To be able to target microRNAs also at stages where these are in a double stranded or hairpin form we have studied BisPNA designed to clamp the target and give...
9.
Ghidini A, Steunenberg P, Murtola M, Stromberg R
Molecules
. 2014 Mar;
19(3):3135-48.
PMID: 24633349
Several different approaches have been explored for conjugation of oligoethers to PNA with internally or N-terminal placed diaminopropionic acid residues. Single and double conjugation of 2-(2-(2-aminoethoxy)ethoxy)ethanol was obtained using carbonyldimidazole....
10.
Kiviniemi A, Murtola M, Ingman P, Virta P
J Org Chem
. 2013 May;
78(11):5153-9.
PMID: 23638811
Peptide nucleic acid (PNA) building blocks, bearing a fluorine sensor at C-5 of the uracil base [viz. trifluoromethyl and 3,3-bis(trifluoromethyl)-4,4,4-trifluorobut-1-ynyl], were synthesized and incorporated to a PNA strand, and their...