Meredith L Stone
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Explore the profile of Meredith L Stone including associated specialties, affiliations and a list of published articles.
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11
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474
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Recent Articles
1.
Liu X, Baer J, Stone M, Knolhoff B, Hogg G, Turner M, et al.
Sci Transl Med
. 2024 Oct;
16(770):eado2402.
PMID: 39441902
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is often resistant to therapy. An immune suppressive tumor microenvironment (TME) and oncogenic mutations in have both been implicated as drivers...
2.
Stone M, Lee J, Lee J, Coho H, Tariveranmoshabad M, Wattenberg M, et al.
Nat Immunol
. 2024 Apr;
25(5):755-763.
PMID: 38641718
T cell infiltration into tumors is a favorable prognostic feature, but most solid tumors lack productive T cell responses. Mechanisms that coordinate T cell exclusion are incompletely understood. Here we...
3.
Li Y, Chang R, Stone M, Delman D, Markowitz K, Xue Y, et al.
Cell Rep Med
. 2024 Feb;
5(2):101397.
PMID: 38307029
Microbes are an integral component of the tumor microenvironment. However, determinants of microbial presence remain ill-defined. Here, using spatial-profiling technologies, we show that bacterial and immune cell heterogeneity are spatially...
4.
Wattenberg M, Coho H, Herrera V, Graham K, Stone M, Xue Y, et al.
Sci Immunol
. 2023 Nov;
8(89):eadj5097.
PMID: 37976347
Myeloid cells facilitate T cell immune evasion in cancer yet are pliable and have antitumor potential. Here, by cotargeting myeloid activation molecules, we leveraged the myeloid compartment as a therapeutic...
5.
Thomas S, Wattenberg M, Choi-Bose S, Uhlik M, Harrison B, Coho H, et al.
Nat Commun
. 2023 Oct;
14(1):6330.
PMID: 37816712
Although macrophages contribute to cancer cell dissemination, immune evasion, and metastatic outgrowth, they have also been reported to coordinate tumor-specific immune responses. We therefore hypothesized that macrophage polarization could be...
6.
Stone M, Lee J, Herrera V, Graham K, Lee J, Huffman A, et al.
JCI Insight
. 2021 Jun;
6(14).
PMID: 34101617
Agonist CD40 antibodies are under clinical development in combination with chemotherapy as an approach to prime for antitumor T cell immunity. However, treatment with anti-CD40 is commonly accompanied by both...
7.
Stone M, Beatty G
Pharmacol Ther
. 2019 Jun;
201:202-213.
PMID: 31158393
Inflammation is a hallmark of cancer. For pancreatic ductal adenocarcinoma (PDAC), malignant cells arise in the context of a brisk inflammatory cell infiltrate surrounded by dense fibrosis that is seen...
8.
Travers M, Brown S, Dunworth M, Holbert C, Wiehagen K, Bachman K, et al.
Cancer Res
. 2019 May;
79(13):3445-3454.
PMID: 31088836
Although ovarian cancer has a low incidence rate, it remains the most deadly gynecologic malignancy. Previous work has demonstrated that the DNMTi 5-Azacytidine (5AZA-C) activates type I interferon signaling to...
9.
Lee J, Stone M, Porrett P, Thomas S, Komar C, Li J, et al.
Nature
. 2019 Mar;
567(7747):249-252.
PMID: 30842658
The liver is the most common site of metastatic disease. Although this metastatic tropism may reflect the mechanical trapping of circulating tumour cells, liver metastasis is also dependent, at least...
10.
Stone M, Chiappinelli K, Li H, Murphy L, Travers M, Topper M, et al.
Proc Natl Acad Sci U S A
. 2018 Sep;
115(37):E8583-E8584.
PMID: 30181297
No abstract available.