Melissa Lieu
Overview
Explore the profile of Melissa Lieu including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
163
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0
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Recent Articles
1.
Perry C, Halawani S, Mukherjee S, Ngaba L, Lieu M, Lee W, et al.
JCI Insight
. 2024 Aug;
9(16).
PMID: 39171530
Friedreich's ataxia (FRDA) is a progressive disorder caused by insufficient expression of frataxin, which plays a critical role in assembly of iron-sulfur centers in mitochondria. Individuals are cognitively normal but...
2.
Coleman R, Eguchi A, Lieu M, Roy R, Barr E, Ibetti J, et al.
Sci Signal
. 2021 Mar;
14(676).
PMID: 33785612
Aberrant changes in gene expression underlie the pathogenesis and progression of pressure-overload heart failure, leading to maladaptive cardiac hypertrophy, ventricular remodeling, and contractile dysfunction. Signaling through the G protein G...
3.
Lieu M, Traynham C, de Lucia C, Pfleger J, Piedepalumbo M, Roy R, et al.
Am J Physiol Heart Circ Physiol
. 2020 Mar;
318(5):H1162-H1175.
PMID: 32216616
Nitric oxide (NO) and -nitrosothiol (SNO) are considered cardio- and vasoprotective substances. We now understand that one mechanism in which NO/SNOs provide cardiovascular protection is through their direct inhibition of...
4.
Lieu M, Koch W
Expert Opin Ther Targets
. 2019 Feb;
23(3):201-214.
PMID: 30701991
One in every four deaths in the United States is attributed to cardiovascular disease, hence the development and employment of novel and effective therapeutics are necessary to improve the quality...
5.
Schumacher S, Gao E, Cohen M, Lieu M, Chuprun J, Koch W
Sci Signal
. 2016 Mar;
9(420):ra30.
PMID: 27016525
G protein-coupled receptor (GPCR) kinases (GRKs) play a critical role in cardiac function by regulating GPCR activity. GRK2 suppresses GPCR signaling by phosphorylating and desensitizing active GPCRs, and through protein-protein...
6.
Pol C, Lieu M, Drosatos K
PPAR Res
. 2015 Dec;
2015:835985.
PMID: 26713088
Over 5 million people in the United States suffer from the complications of heart failure (HF), which is a rapidly expanding health complication. Disorders that contribute to HF include ischemic...
7.
Wang T, Xiao M, Ge Y, Krepler C, Belser E, Lopez-Coral A, et al.
Clin Cancer Res
. 2015 Jan;
21(7):1652-64.
PMID: 25617424
Purpose: To investigate the roles of melanoma-associated macrophages in melanoma resistance to BRAF inhibitors (BRAFi). Experimental Design: An in vitro macrophage and melanoma cell coculture system was used to investigate...
8.
Wang T, Ge Y, Xiao M, Lopez-Coral A, Li L, Roesch A, et al.
J Invest Dermatol
. 2013 Oct;
134(4):1108-1118.
PMID: 24157461
Tumor-associated macrophages (TAMs) have essential roles in tumor progression and metastasis. Tumor cells recruit myeloid progenitors and monocytes to the tumor site, where they differentiate into TAMs; however, this process...