Melissa C Kapulu
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Explore the profile of Melissa C Kapulu including associated specialties, affiliations and a list of published articles.
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26
Citations
506
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Recent Articles
1.
Kinyua A, Turner L, Kimingi H, Mwai K, Mwikali K, Andisi C, et al.
J Infect
. 2024 Aug;
89(4):106252.
PMID: 39182654
Objectives: Acquisition of antibodies to Plasmodium falciparum variant surface antigens (VSA) expressed on infected red blood cells (iRBCs) is associated with naturally acquired immunity to malaria. We have previously shown...
2.
Rosenkranz M, Nkumama I, Ogwang R, Kraker S, Blickling M, Mwai K, et al.
Life Sci Alliance
. 2024 May;
7(8).
PMID: 38803222
The merozoite surface protein 1 (MSP1) is the most abundant protein on the surface of the invasive merozoite stages of and has long been considered a key target of protective...
3.
Nkumama I, Ogwang R, Odera D, Musasia F, Mwai K, Nyamako L, et al.
Immunity
. 2024 May;
57(6):1215-1224.e6.
PMID: 38788711
Malaria is a life-threatening disease of global health importance, particularly in sub-Saharan Africa. The growth inhibition assay (GIA) is routinely used to evaluate, prioritize, and quantify the efficacy of malaria...
4.
Kapulu M, Muthumbi E, Otieno E, Rossi O, Ferruzzi P, Necchi F, et al.
Front Immunol
. 2024 Feb;
15:1340425.
PMID: 38361949
Background: Shigellosis mainly affects children under 5 years of age living in low- and middle-income countries, who are the target population for vaccination. There are, however, limited data available to...
5.
Kariuki S, Macharia A, Makale J, Nyamu W, Hoffman S, Kapulu M, et al.
Elife
. 2023 Jun;
12.
PMID: 37310872
Background: The long co-evolution of and has resulted in the selection of numerous human genetic variants that confer an advantage against severe malaria and death. One such variant is the...
6.
Odera D, Tuju J, Mwai K, Nkumama I, Furle K, Chege T, et al.
Sci Transl Med
. 2023 Feb;
15(682):eabn5993.
PMID: 36753561
Natural killer (NK) cells are potent immune effectors that can be activated via antibody-mediated Fc receptor engagement. Using multiparameter flow cytometry, we found that NK cells degranulate and release IFN-γ...
7.
Kapulu M, Nakakana U, Scire A, Sarakinou E, Conti V, Rossi O, et al.
Front Immunol
. 2022 Oct;
13:971866.
PMID: 36203568
is associated with a significant burden of disease worldwide among individuals of all ages and is the major cause of moderate and severe diarrhea in children under five years of...
8.
Musasia F, Nkumama I, Frank R, Kipkemboi V, Schneider M, Mwai K, et al.
Nat Commun
. 2022 Jul;
13(1):4098.
PMID: 35835738
Ring-infected erythrocytes are the predominant asexual stage in the peripheral circulation but are rarely investigated in the context of acquired immunity against Plasmodium falciparum malaria. Here we compare antibody-dependent phagocytosis...
9.
Clarkson K, Porter C, Talaat K, Kapulu M, Chen W, Frenck Jr R, et al.
Curr Top Microbiol Immunol
. 2022 May;
445:257-313.
PMID: 35616717
Shigella-controlled human infection models (CHIMs) are an invaluable tool utilized by the vaccine community to combat one of the leading global causes of infectious diarrhea, which affects infants, children and...
10.
Mumba N, Njuguna P, Chi P, Marsh V, Awuor E, Hamaluba M, et al.
Front Public Health
. 2022 May;
10:793913.
PMID: 35570883
Human infection studies (HIS) involve deliberately infecting healthy volunteers with disease-causing pathogens under controlled conditions. These studies are "controlled" by way of using specific types of pathogens, including dose, and...