Melisa Lazaro
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Explore the profile of Melisa Lazaro including associated specialties, affiliations and a list of published articles.
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11
Citations
269
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Recent Articles
1.
Erana H, Diaz-Dominguez C, Charco J, Vidal E, Gonzalez-Miranda E, Perez-Castro M, et al.
Acta Neuropathol Commun
. 2023 Sep;
11(1):145.
PMID: 37679832
Among transmissible spongiform encephalopathies or prion diseases affecting humans, sporadic forms such as sporadic Creutzfeldt-Jakob disease are the vast majority. Unlike genetic or acquired forms of the disease, these idiopathic...
2.
Iriondo M, Etxaniz A, Varela Y, Ballesteros U, Lazaro M, Valle M, et al.
Cell Mol Life Sci
. 2023 Feb;
80(2):56.
PMID: 36729310
In macroautophagy, the autophagosome (AP) engulfs portions of cytoplasm to allow their lysosomal degradation. AP formation in humans requires the concerted action of the ATG12 and LC3/GABARAP conjugation systems. The...
3.
Author Correction: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase
Lopez-Alonso J, Lazaro M, Gil-Carton D, Choi P, Dodu A, Tong L, et al.
Nat Commun
. 2022 Nov;
13(1):7009.
PMID: 36385225
No abstract available.
4.
Lopez-Alonso J, Lazaro M, Gil-Carton D, Choi P, Dodu A, Tong L, et al.
Nat Commun
. 2022 Oct;
13(1):6185.
PMID: 36261450
Pyruvate carboxylase (PC) is a tetrameric enzyme that contains two active sites per subunit that catalyze two consecutive reactions. A mobile domain with an attached prosthetic biotin links both reactions,...
5.
Ballesteros U, Etxaniz A, Iriondo M, Varela Y, Lazaro M, Viguera A, et al.
Int J Biol Macromol
. 2022 May;
212:432-441.
PMID: 35618088
Autophagy is a process in which parts of the eukaryotic cell are selectively degraded in the lysosome. The materials to be catabolized are first surrounded by a double-membrane structure, the...
6.
Lazaro M, Melero R, Huet C, Lopez-Alonso J, Delgado S, Dodu A, et al.
Commun Biol
. 2021 Jun;
4(1):684.
PMID: 34083757
Glutamate dehydrogenases (GDHs) are widespread metabolic enzymes that play key roles in nitrogen homeostasis. Large glutamate dehydrogenases composed of 180 kDa subunits (L-GDHs) contain long N- and C-terminal segments flanking...
7.
Fernandez-Millan P, Lazaro M, Cansiz-Arda S, Gerhold J, Rajala N, Schmitz C, et al.
Nucleic Acids Res
. 2015 Apr;
43(8):4284-95.
PMID: 25824949
The mitochondrial replicative helicase Twinkle is involved in strand separation at the replication fork of mitochondrial DNA (mtDNA). Twinkle malfunction is associated with rare diseases that include late onset mitochondrial...
8.
Lasso G, Yu L, Gil D, Lazaro M, Tong L, Valle M
Structure
. 2014 Jun;
22(6):911-22.
PMID: 24882745
The tetrameric enzyme pyruvate carboxylase (PC), a biotin-dependent carboxylase, produces oxaloacetate by two consecutive reactions that take place in distant active sites. Previous crystal structures revealed two different configurations for...
9.
Melero R, Buchwald G, Castano R, Raabe M, Gil D, Lazaro M, et al.
Nat Struct Mol Biol
. 2012 Apr;
19(5):498-505, S1-2.
PMID: 22522823
Nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance pathway that degrades aberrant mRNAs containing premature termination codons (PTCs). NMD is triggered upon the assembly of the UPF surveillance complex near...
10.
Melero R, Rajagopalan S, Lazaro M, Joerger A, Brandt T, Veprintsev D, et al.
Proc Natl Acad Sci U S A
. 2010 Dec;
108(2):557-62.
PMID: 21178074
The multidomain homotetrameric tumor suppressor p53 has two modes of binding dsDNA that are thought to be responsible for scanning and recognizing specific response elements (REs). The C termini bind...