Melanie V Leveridge
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Explore the profile of Melanie V Leveridge including associated specialties, affiliations and a list of published articles.
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5
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48
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Recent Articles
1.
Muller L, Burton A, Tayler C, Rowedder J, Hutchinson J, Peace S, et al.
SLAS Discov
. 2022 Nov;
28(1):3-11.
PMID: 36414185
MALDI-TOF MS is a powerful analytical technique that provides a fast and label-free readout for in vitro assays in the high-throughput screening (HTS) environment. Here, we describe the development of...
2.
Douthwaite J, Brown C, Ferdinand J, Sharma R, Elliott J, Taylor M, et al.
Sci Rep
. 2022 Feb;
12(1):3114.
PMID: 35210470
On 11th March 2020, the UK government announced plans for the scaling of COVID-19 testing, and on 27th March 2020 it was announced that a new alliance of private sector...
3.
Deaton D, Do Y, Holt J, Jeune M, Kramer H, Larkin A, et al.
Bioorg Med Chem
. 2019 Mar;
27(8):1456-1478.
PMID: 30858025
With the goal of discovering more selective anti-inflammatory drugs, than COX inhibitors, to attenuate prostaglandin signaling, a fragment-based screen of hematopoietic prostaglandin D synthase was performed. The 76 crystallographic hits...
4.
Leveridge M, Bardera A, Lamarr W, Billinton A, Bellenie B, Edge C, et al.
J Biomol Screen
. 2012 Feb;
17(5):641-50.
PMID: 22337655
Microsomal prostaglandin E synthase-1 (mPGES-1) represents an attractive target for the treatment of rheumatoid arthritis and pain, being upregulated in response to inflammatory stimuli. Biochemical assays for prostaglandin E synthase...
5.
Hutchinson S, Leveridge M, Heathcote M, Francis P, Williams L, Gee M, et al.
J Biomol Screen
. 2011 Aug;
17(1):39-48.
PMID: 21859681
A high-throughput RapidFire mass spectrometry assay is described for the JMJD2 family of Fe(2+), O(2), and α-ketoglutarate-dependent histone lysine demethylases. The assay employs a short amino acid peptide substrate, corresponding...