Melanie Reschke
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Explore the profile of Melanie Reschke including associated specialties, affiliations and a list of published articles.
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10
Citations
229
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Recent Articles
1.
Suberi A, Grun M, Mao T, Israelow B, Reschke M, Grundler J, et al.
Sci Transl Med
. 2023 Aug;
15(709):eabq0603.
PMID: 37585505
An inhalable platform for messenger RNA (mRNA) therapeutics would enable minimally invasive and lung-targeted delivery for a host of pulmonary diseases. Development of lung-targeted mRNA therapeutics has been limited by...
2.
Mao T, Israelow B, Pena-Hernandez M, Suberi A, Zhou L, Luyten S, et al.
Science
. 2022 Oct;
378(6622):eabo2523.
PMID: 36302057
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has highlighted the need for vaccines that not only prevent disease but also prevent transmission. Parenteral vaccines induce robust systemic immunity...
3.
Reschke M, Piotrowski-Daspit A, Pober J, Saltzman W
Mol Pharm
. 2022 Oct;
19(12):4466-4486.
PMID: 36251765
This Review examines the state-of-the-art in the delivery of nucleic acid therapies that are directed to the vascular endothelium. First, we review the most important homeostatic functions and properties of...
4.
Chen A, Xiao Y, Tang X, Baqri M, Gao X, Reschke M, et al.
Neuro Oncol
. 2022 Jul;
25(3):482-494.
PMID: 35901838
Background: Improved treatment of glioblastoma (GBM) needs to address tumor invasion, a hallmark of the disease that remains poorly understood. In this study, we profiled GBM invasion through integrative analysis...
5.
Shin K, Suh H, Grundler J, Lynn A, Pothupitiya J, Moscato Z, et al.
Biomaterials
. 2022 Jul;
287:121676.
PMID: 35849999
Poly(ethylene glycol) (PEG) is widely employed for passivating nanoparticle (NP) surfaces to prolong blood circulation and enhance localization of NPs to target tissue. However, the immune response of PEGylated NPs-including...
6.
Suberi A, Grun M, Mao T, Israelow B, Reschke M, Grundler J, et al.
bioRxiv
. 2022 Mar;
PMID: 35350207
One-sentence Summary: Inhaled polymer nanoparticles (NPs) achieve high mRNA expression in the lung and induce protective immunity against SARS-CoV-2.
7.
Mao T, Israelow B, Suberi A, Zhou L, Reschke M, Pena-Hernandez M, et al.
bioRxiv
. 2022 Feb;
PMID: 35118464
One-sentence Summary: Broad sarbecovirus protective mucosal immunity is generated by unadjuvanted intranasal spike boost in preclinical model.
8.
Reschke M, DiRito J, Stern D, Day W, Plebanek N, Harris M, et al.
Bioeng Transl Med
. 2022 Feb;
7(1):e10242.
PMID: 35111944
In preclinical research, histological analysis of tissue samples is often limited to qualitative or semiquantitative scoring assessments. The reliability of this analysis can be impaired by the subjectivity of these...
9.
DiRito J, Hosgood S, Reschke M, Albert C, Bracaglia L, Ferdinand J, et al.
Am J Transplant
. 2020 Jul;
21(1):161-173.
PMID: 32627324
Thousands of kidneys from higher-risk donors are discarded annually because of the increased likelihood of complications posttransplant. Given the severe organ shortage, there is a critical need to improve utilization...
10.
Merola J, Reschke M, Pierce R, Qin L, Spindler S, Baltazar T, et al.
JCI Insight
. 2019 Sep;
4(20).
PMID: 31527312
Tissue engineering may address organ shortages currently limiting clinical transplantation. Off-the-shelf engineered vascularized organs will likely use allogeneic endothelial cells (ECs) to construct microvessels required for graft perfusion. Vasculogenic ECs...