Melanie Heroult
Overview
Explore the profile of Melanie Heroult including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
23
Citations
1177
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0
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Recent Articles
1.
Lerchen H, Stelte-Ludwig B, Heroult M, Zubov D, Gericke K, Wong H, et al.
Cancers (Basel)
. 2023 Sep;
15(17).
PMID: 37686656
The emerging field of small-molecule-drug conjugates (SMDCs) using small-molecule biomarker-targeted compounds for tumor homing may provide new perspectives for targeted delivery. Here, for the first time, we disclose the structure...
2.
Lerchen H, Stelte-Ludwig B, Kopitz C, Heroult M, Zubov D, Willuda J, et al.
Cancers (Basel)
. 2022 Jan;
14(2).
PMID: 35053556
To improve tumor selectivity of cytotoxic agents, we designed VIP236, a small molecule-drug conjugate consisting of an αβ integrin binder linked to a modified camptothecin payload (VIP126), which is released...
3.
Grunewald S, Politz O, Bender S, Heroult M, Lustig K, Thuss U, et al.
Int J Cancer
. 2019 Feb;
145(5):1346-1357.
PMID: 30807645
Aberrant activation in fibroblast growth factor signaling has been implicated in the development of various cancers, including squamous cell lung cancer, squamous cell head and neck carcinoma, colorectal and bladder...
4.
Collin M, Lobell M, Hubsch W, Brohm D, Schirok H, Jautelat R, et al.
ChemMedChem
. 2018 Feb;
13(5):437-445.
PMID: 29451369
Rogaratinib (BAY 1163877) is a highly potent and selective small-molecule pan-fibroblast growth factor receptor (FGFR) inhibitor (FGFR1-4) for oral application currently being investigated in phase 1 clinical trials for the...
5.
Basit F, van Oppen L, Schockel L, Bossenbroek H, van Emst-de Vries S, Hermeling J, et al.
Cell Death Dis
. 2017 Mar;
8(3):e2716.
PMID: 28358377
Inhibition of complex I (CI) of the mitochondrial respiratory chain by BAY 87-2243 ('BAY') triggers death of BRAF melanoma cell lines and inhibits in vivo tumor growth. Here we studied...
6.
Roth L, Prahst C, Ruckdeschel T, Savant S, Westrom S, Fantin A, et al.
Sci Signal
. 2016 Apr;
9(425):ra42.
PMID: 27117252
Neuropilin-1 (NRP1) regulates developmental and pathological angiogenesis, arteriogenesis, and vascular permeability, acting as a coreceptor for semaphorin 3A (Sema3A) and the 165-amino acid isoform of vascular endothelial growth factor A...
7.
Schockel L, Glasauer A, Basit F, Bitschar K, Truong H, Erdmann G, et al.
Cancer Metab
. 2015 Oct;
3:11.
PMID: 26500770
Background: Numerous studies have demonstrated that functional mitochondria are required for tumorigenesis, suggesting that mitochondrial oxidative phosphorylation (OXPHOS) might be a potential target for cancer therapy. In this study, we...
8.
Kaspiris A, Mikelis C, Heroult M, Khaldi L, Grivas T, Kouvaras I, et al.
Joint Bone Spine
. 2013 Jan;
80(4):407-13.
PMID: 23333521
Objectives: Pleiotrophin is a heparin-binding growth factor expressed in embryonic but not mature cartilage, suggesting a role in cartilage development. Elucidation of the molecular changes observed during the remodelling process...
9.
Heroult M, Schaffner F, Pfaff D, Prahst C, Kirmse R, Kutschera S, et al.
Mol Cancer Res
. 2010 Nov;
8(10):1297-309.
PMID: 21047731
The tyrosine kinase receptor EphB4 interacts with its ephrinB2 ligand to act as a bidirectional signaling system that mediates adhesion, migration, and guidance by controlling attractive and repulsive activities. Recent...
10.
Kutschera S, Weber H, Weick A, De Smet F, Genove G, Takemoto M, et al.
Arterioscler Thromb Vasc Biol
. 2010 Oct;
31(1):151-9.
PMID: 20947821
Objective: To characterize the role of a vascular-expressed class 3 semaphorin (semaphorin 3G [Sema3G]). Methods And Results: Semaphorins have been identified as axon guidance molecules. Yet, they have more recently...